Category: Medium & Serums

August 24, 2020

Research for Disulfide-Linked, Self-Immolating Subsequent-Technology Antibody Drug

Conjugation Site Influences Antibody-Conjugated Drug PK Assays: Case Studies for Disulfide-Linked, Self-Immolating Next-Generation Antibody Drug Conjugates   Immunoaffinity (IA) LC-MS/MS pharmacokinetic (PK) assays are widely used in the field for antibody drug conjugates (ADCs) containing peptide linkers that are enzymatically cleavable, such as MC-ValCit-PAB. Conjugate PK assay strategies for these ADCs involve cleavage with cathepsin B or papain to release and measure the antibody-conjugated drug (acDrug) concentration. However, […]

August 24, 2020

Antibody-Protein binding and Conformational changes

A high-throughput neutralizing antibody assay for COVID-19 analysis and vaccine analysis   Virus neutralization stays the gold normal for figuring out antibody efficacy. Due to this fact, a high-throughput assay to measure SARS-CoV-2 neutralizing antibodies is urgently wanted for COVID-19 serodiagnosis, convalescent plasma remedy, and vaccine growth. Right here, we report on a fluorescence-based SARS-CoV-2 neutralization assay that detects SARS-CoV-2 neutralizing antibodies in COVID-19 affected person […]