Antibody profiling of a Borreliella burgdorferi (Lyme illness) C6 antibody constructive, symptomatic Rottweiler and her pups
Lyme illness (LD) is a tick-transmitted illness attributable to Borreliella burgdorferi (Bb). Temporal research of maternal antibody (Ab) profiles in Bb contaminated pregnant canines and their pups haven’t been carried out. On this research, Ab profiles of a client-owned Bb C6 Ab constructive Rottweiler and her 9 pups have been assessed.
The dam introduced with lameness 12 days previous to parturition and was C6 Ab constructive with a Quant C6 Ab focus of 237U/mL. Remedy with amoxicillin was initiated and 11 days later 9 pups have been delivered. Screening of the sera from the dam and pups towards Bb cell lysates and a panel of antigens revealed related immunoreactivity profiles.
Whereas antigen-specific IgG and IgM reactivity persevered within the dam for at the least 7 months, a speedy decline in IgG particular for BBA36, BBK53, BB0238, BBA73 and outer floor protein (Osp) E within the pups occurred between days 29 and 52 post-parturition. In distinction, Ab particular for DbpA and the diagnostic antigens VlsE (C6) and OspF, remained elevated within the pups.
Sera from the dam displayed potent complement-dependent bactericidal exercise towards Bb. Sera from the pups was additionally bactericidal however primarily by a complement-independent mechanism. Lastly, single dose vaccination of the dam at day 51 post-parturition with a LD subunit vaccine consisting of OspA and an OspC chimeritope triggered a broad anti-OspC Ab response indicative of an anamnestic response.
Though this research targeted on a single case, these findings add to our information of maternal Ab profiles and can help the interpretation of serological assays in pups delivered by a Bb C6 Ab constructive canine.
Binding mechanisms of therapeutic antibodies to human CD20
Monoclonal antibodies (mAbs) focusing on human antigen CD20 (cluster of differentiation 20) represent essential immunotherapies for the remedy of B cell malignancies and autoimmune ailments. Kind I and II therapeutic mAbs differ in B cell binding properties and cytotoxic results, reflecting differential interplay mechanisms with CD20. Right here we current 3.7- to 4.7-angstrom cryo-electron microscopy buildings of full-length CD20 in complexes with prototypical sort I rituximab and ofatumumab and sort II obinutuzumab.
The buildings and binding thermodynamics show that upon binding to CD20, sort II mAbs kind terminal complexes that preclude recruitment of further mAbs and complement parts, whereas sort I complexes act as molecular seeds to extend mAb native focus for environment friendly complement activation. Amongst sort I mAbs, ofatumumab complexes show optimum geometry for complement recruitment. The uncovered mechanisms ought to help rational design of next-generation immunotherapies focusing on CD20.
genediag
Anti-Human Galectin-1 Antibody |
102-PA131S |
ReliaTech |
100 µg |
EUR 126 |
Description: Galectin-1, also known as L14, BHL and galaptin, is a monomeric or homodimeric prototype galectin that is expressed in a variety of cells and tissues including muscle, heart, liver, prostate, lymph nodes, spleen, thymus, placenta, testis, retina, macrophages, B cells, T cells, dendritic cells, and tumor cells. It preferentially binds laminin, fibronectin, 90K/Mac2BP, CD45, CD43, CD7, CD2, CD3, and ganglioside GM1. Galectin-1 modulates cell growth and proliferation, either positively or negatively, depending on the cell type and activation status. It controls cell survival by inducing apoptosis of activated T cells and immature thymocytes. It modulates cytokine secretion by inducing Th2 type cytokines and inhibiting proinflammatory cytokine production. Galectin1 can also modulate cel-lcell as well as cell-lmatrix interactions and depending on the cell type and developmental stage, promote cell attachment or detachment. Galectin-1 has immunosuppressive and antiinflammatory properties and has been shown to suppress acute and chronic inflammation and autoimmunity. Human and mouse galectin1 share about 88% amino acid sequence similarity. |
Anti- Galectin-1 Antibody |
GWB-6F6392 |
GenWay Biotech |
0.1 mg |
Ask for price |
anti- Galectin-1 antibody |
FNab03314 |
FN Test |
100µg |
EUR 606.3 |
|
Description: Antibody raised against Galectin-1 |
anti- Galectin-1 antibody |
FNab03315 |
FN Test |
100µg |
EUR 658.5 |
|
Description: Antibody raised against Galectin-1 |
Human Galectin-1 (Gal-1) Antibody |
30005-05111 |
AssayPro |
150 ug |
EUR 215 |
Human Galectin-1 (LGALS1) |
1-CSB-EP012882HU |
Cusabio |
-
Ask for price
-
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-
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-
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-
Ask for price
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
Description: Recombinant Human Galectin-1(LGALS1) expressed in E.coli |
Human Galectin-1 (LGALS1) |
1-CSB-EP012882HUb1 |
Cusabio |
-
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-
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-
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-
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-
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-
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|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
Description: Recombinant Human Galectin-1(LGALS1) expressed in E.coli |
human anti-human galectin-3 mAb(2D) |
E4A09H10-2D |
EnoGene |
50ug |
EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
human anti-human galectin-3 mAb(5F) |
E4A09H10-5F |
EnoGene |
50ug |
EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
human anti-human galectin-3 mAb(A5) |
E4A09H10-A5 |
EnoGene |
50ug |
EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
human anti-human galectin-3 mAb(G2) |
E4A09H10-G2 |
EnoGene |
50ug |
EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
human anti-human galectin-3 mAb(H3) |
E4A09H10-H3 |
EnoGene |
50ug |
EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
human anti-human galectin-3 mAb(T1) |
E4A09H10-T1 |
EnoGene |
50ug |
EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
human anti-human galectin-3 mAb(N13) |
E4A09H10-N13 |
EnoGene |
50ug |
EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
Anti Human Galectin-3 Polyclonal Antibody |
KH040 |
Sceti |
each |
EUR 778.8 |
Description: The Anti Human Galectin-3 Polyclonal Antibody is available in Europe and for worldwide shipping via Gentaur. |
Recombinant Human Galectin-1 |
7-00427 |
CHI Scientific |
10µg |
Ask for price |
Recombinant Human Galectin-1 |
7-00428 |
CHI Scientific |
50µg |
Ask for price |
Recombinant Human Galectin-1 |
AP60482 |
SAB |
100ug |
EUR 449 |
|
Recombinant Human Galectin-1 |
HEOPP-0710 |
Cyagen |
10ug |
Ask for price |
RECOMBINANT HUMAN GALECTIN-1 |
GWB-BEA2B0 |
GenWay Biotech |
0.05 mg |
Ask for price |
Recombinant Human Galectin-1 |
cyt-544-10g |
ProSpec Tany |
10µg |
EUR 60 |
Recombinant Human Galectin-1 |
cyt-544-1mg |
ProSpec Tany |
1mg |
EUR 1350 |
Recombinant Human Galectin-1 |
cyt-544-50g |
ProSpec Tany |
50µg |
EUR 145 |
Human Galectin 1 Protein |
20-abx066725 |
Abbexa |
-
Ask for price
-
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-
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-
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-
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|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Human Galectin-1 Antibody Pair Set |
ABPR-ZB244 |
Creative Diagnostics |
5 plates, 15 plates |
Ask for price |
Description: Quantitative determination of Human Galectin-1 |
Galectin-1, human recombinant |
4648-10 |
Biovision |
each |
EUR 170.4 |
Galectin-1, human recombinant |
4648-1000 |
Biovision |
each |
EUR 1977.6 |
Galectin-1, human recombinant |
4648-50 |
Biovision |
each |
EUR 314.4 |
Galectin-1 Human Recombinant |
rAP-2252 |
Angio Proteomie |
Inquiry |
Ask for price |
Human Galectin-1 ELISA Kit |
EK5323 |
SAB |
96 tests |
EUR 599 |
|
Human Galectin-1 ELISA Kit |
IHULGALS1KT |
Innovative research |
each |
EUR 702 |
|
Description: Human Galectin-1 ELISA Kit |
Mouse Monoclonal anti-human Galectin-1 |
hAP-1228 |
Angio Proteomie |
50ug |
EUR 400 |
Sheep Polyclonal anti-Human Galectin-1 |
hAP-5905 |
Angio Proteomie |
50ug |
EUR 400 |
Anti-Mouse Galectin-1 Antibody |
103-M223 |
ReliaTech |
100 µg |
EUR 399 |
Description: The galectins constitute a large family of carbohydrate-binding proteins that function in many systems both intracellularly and following secretion. Galectins contain either one or two carbohydrate recognition domains (CRR) which mediate recognition of N-acetyl-lactosamine-containing glycoproteins. Some galectins exist in multiple isoforms due to alternative splicing. Individual galectins differ in their tissue distribution and in their carbohydrate-binding specificities. |
Human Galectin-1 (LEG1) Protein |
abx690252-100g |
Abbexa |
100 µg |
EUR 837.5 |
Human Galectin-1 (LEG1) Protein |
abx690252-20g |
Abbexa |
20 µg |
EUR 350 |
Human Galectin-1 (LGALS1) Protein |
abx670211-50ug |
Abbexa |
50 ug |
EUR 661.2 |
|
Human Galectin 1 ELISA kit |
E01A4669 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Human Galectin 1 ELISA kit |
E01G0038-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A sandwich ELISA for quantitative measurement of Human Galectin 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Galectin 1 ELISA kit |
E01G0038-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A sandwich ELISA for quantitative measurement of Human Galectin 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Galectin 1 ELISA kit |
E01G0038-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A sandwich ELISA for quantitative measurement of Human Galectin 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Galectin 1 ELISA Kit |
IHUGAL1KT |
Innovative research |
each |
EUR 667 |
|
Description: Human Galectin 1 ELISA Kit |
Galectin-10, Human |
E34M155H |
EnoGene |
5 μg |
EUR 155 |
Galectin-12, Human |
E34M156H |
EnoGene |
5 μg |
EUR 155 |
Galectin-13, Human |
E34M157H |
EnoGene |
5 μg |
EUR 155 |
Galectin-14, Human |
E34M158H |
EnoGene |
5 μg |
EUR 155 |
Galectin-16, Human |
E34M159H |
EnoGene |
5 μg |
EUR 155 |
Galectin-2, Human |
E34M149H |
EnoGene |
5 μg |
EUR 155 |
Galectin-3, Human |
E34M150H |
EnoGene |
5 μg |
EUR 155 |
Galectin-4, Human |
E34M151H |
EnoGene |
5 μg |
EUR 155 |
Galectin-7, Human |
E34M152H |
EnoGene |
5 μg |
EUR 155 |
Galectin-8, Human |
E34M153H |
EnoGene |
5 μg |
EUR 155 |
Galectin-9, Human |
E34M154H |
EnoGene |
5 μg |
EUR 155 |
Anti-Human Galectin-3 Antibody |
101-M424 |
ReliaTech |
100 µg |
EUR 399 |
Description: The galectins constitute a large family of carbohydrate-binding proteins that function in many systems both intracellularly and following secretion. Galectins contain either one or two carbohydrate recognition domains (CRR) which mediate recognition of N-acetyl-lactosamine-containing glycoproteins. Some galectins exist in multiple isoforms due to alternative splicing. Individual galectins differ in their tissue distribution and in their carbohydrate-binding specificities. |
Anti-Human Galectin-4 Antibody |
101-M425 |
ReliaTech |
100 µg |
EUR 399 |
Description: Galectin-4 is a member of the subfamily of galectins composed of two carbohydrate recognition domains having similar peptide chains. The galectins are a family of beta-galactoside-binding proteins having a role in modulating cell-cell and cell-matrix interactions, which inhibits chronic inflammations, GVHD, and allergic responses. LGALS4 expression is limited to small intestine, colon, and rectum, and it is underexpressed in colorectal cancer. LGALS4 binds as an endogenous ligand to glycosphingolipids having 3-O-sulfated Gal residues and bind as well to cholesterol-3-sulfate. LGALS4 takes part in cell adhesion. LGALS4 plays a role in crosslinking the lateral cell membranes of the surface-lining epithelial cells, thus supporting epithelial integrity against mechanical stress exerted by the bowel lume. |
Anti-Human Galectin-8 Antibody |
101-M427 |
ReliaTech |
100 µg |
EUR 399 |
Description: LGALS8 is a prostate-specific antigen that is solely overexpressed in malignant tumors and thus is a supplementary specific identifier of malignancies. LGALS8 is part of the galectin gene family which facilitates both cell-cell and cell matrix interactions in a method parallel to the selectin subgroup of C-type lectins. |
Anti-Human Galectin-3 Antibody |
101-M747 |
ReliaTech |
100 µg |
EUR 399 |
Description: The galectins constitute a large family of carbohydrate-binding proteins that function in many systems both intracellularly and following secretion. Galectins contain either one or two carbohydrate recognition domains (CRR) which mediate recognition of N-acetyl-lactosamine-containing glycoproteins. Some galectins exist in multiple isoforms due to alternative splicing. Individual galectins differ in their tissue distribution and in their carbohydrate-binding specificities. |
Anti-Human Galectin-7 Antibody |
101-M748 |
ReliaTech |
100 µg |
EUR 399 |
Description: Galectin-7 is a protein that in humans is encoded by the LGALS7 gene. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell–cell and cell–matrix interactions. Differential and in situ hybridizations indicate that this lectin is specifically expressed in keratinocytes. It is expressed at all stages of epidermal differentiation (i.e., in basal and supra-basal layers). It is moderately repressed by retinoic acid. The protein was found mainly in stratified squamous epithelium. The antigen localized to basal keratinocytes, although it was also found, albeit at lower levels, in the supra-basal layers where it concentrated to areas of cell-to-cell contact. The cellular localization and it’s striking down-regulation in cultured keratinocytes imply a role in cell–cell and/or cell–matrix interactions necessary for normal growth control. |
Anti-Human Galectin-3 Antibody |
102-P228 |
ReliaTech |
100 µg |
EUR 245.7 |
Description: The galectins constitute a large family of carbohydrate-binding proteins that function in many systems both intracellularly and following secretion. Galectins contain either one or two carbohydrate recognition domains (CRR) which mediate recognition of N-acetyl-lactosamine-containing glycoproteins. Some galectins exist in multiple isoforms due to alternative splicing. Individual galectins differ in their tissue distribution and in their carbohydrate-binding specificities. |
anti-human Galectin-3 antibody |
10-2887 |
Fitzgerald |
250 ug |
EUR 410 |
|
Description: Purified anti-human Galectin-3 antibody |
Anti-human Galectin-3 antibody |
STJ15100163 |
St John's Laboratory |
250 µg |
EUR 403.2 |
Description: This monoclonal antibody is for studies of antigen expression in cells and tissue sections using immunocytochemistry and immunoprecipitation |
Recombinant Human Galectin-1(LGALS1) |
AP70493 |
SAB |
1mg |
EUR 1978 |
|
Recombinant Human Galectin-1 (LGALS1) |
CSB-EP012882HU |
Cusabio |
1598 mg |
Ask for price |
Recombinant Human Galectin-1 (LGALS1) |
CSB-EP012882HUb1 |
Cusabio |
1599 mg |
Ask for price |
Recombinant Human Galectin-1 (LGALS1) |
Z101845 |
ABM |
15 µg |
EUR 105 |
Description: Galectin-1 is a member of the galectin family, and binds B-galactosidase moieties on glycoproteins or glycolipids. Galectins are primarily involved in modulation of cell-cell and cell-matrix interactions. Galectin-1 acts as a negative regulator of immunity, promoting immune suppression and lessening the inflammatory response. Galectin-1 binds CD45, CD3 and CD4, resulting in the inhibition of CD45 phosphatase dependant dephosphorylation of lyn kinase, as well as a number of other immune related receptors. Due to its function as a negative regulator of the immune response, and role inducing apoptosis in activated Th1 and Th17 cells, it is commonly found upregulated around malignant tumours. It has also been implicated as having a role in the development of immune tolerance during pregnancy, and is highly expressed at the maternal-fetal interface. As a dimer it down-regulates neutrophils by inducing exposure of phosphatidylserine, thereby marking the cell for apoptosis. It shares approximately 88% and 90% sequence similarity with mouse and rat galectin-1, respectively. Recombinant Human Galectin-1 is a 14.9kDa protein. |
Recombinant Human Galectin-1 (LGALS1) |
Z101847 |
ABM |
100 µg |
EUR 270 |
Description: Galectin-1 is a member of the galectin family, and binds B-galactosidase moieties on glycoproteins or glycolipids. Galectins are primarily involved in modulation of cell-cell and cell-matrix interactions. Galectin-1 acts as a negative regulator of immunity, promoting immune suppression and lessening the inflammatory response. Galectin-1 binds CD45, CD3 and CD4, resulting in the inhibition of CD45 phosphatase dependant dephosphorylation of lyn kinase, as well as a number of other immune related receptors. Due to its function as a negative regulator of the immune response, and role inducing apoptosis in activated Th1 and Th17 cells, it is commonly found upregulated around malignant tumours. It has also been implicated as having a role in the development of immune tolerance during pregnancy, and is highly expressed at the maternal-fetal interface. As a dimer it down-regulates neutrophils by inducing exposure of phosphatidylserine, thereby marking the cell for apoptosis. It shares approximately 88% and 90% sequence similarity with mouse and rat galectin-1, respectively. Recombinant Human Galectin-1 is a 14.9kDa protein. |
Recombinant Human Galectin-1 (LGALS1) |
Z101849 |
ABM |
1.0 mg |
EUR 1135 |
Description: Galectin-1 is a member of the galectin family, and binds B-galactosidase moieties on glycoproteins or glycolipids. Galectins are primarily involved in modulation of cell-cell and cell-matrix interactions. Galectin-1 acts as a negative regulator of immunity, promoting immune suppression and lessening the inflammatory response. Galectin-1 binds CD45, CD3 and CD4, resulting in the inhibition of CD45 phosphatase dependant dephosphorylation of lyn kinase, as well as a number of other immune related receptors. Due to its function as a negative regulator of the immune response, and role inducing apoptosis in activated Th1 and Th17 cells, it is commonly found upregulated around malignant tumours. It has also been implicated as having a role in the development of immune tolerance during pregnancy, and is highly expressed at the maternal-fetal interface. As a dimer it down-regulates neutrophils by inducing exposure of phosphatidylserine, thereby marking the cell for apoptosis. It shares approximately 88% and 90% sequence similarity with mouse and rat galectin-1, respectively. Recombinant Human Galectin-1 is a 14.9kDa protein. |
Human Galectin-1 ELISA ELISA Kit |
E16HE0311 |
EnoGene |
96T |
EUR 1000 |
Human Galectin-1 Recombinant Protein |
100-175 |
ReliaTech |
50 µg |
EUR 196.35 |
Description: Lectins, of either plant or animal origin, are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. The Galectins are lectins that recognize and interact with β-galactoside moieties. Galectin-1 is an animal lectin that has been shown to interact with CD3, CD4, and CD45. It induces apoptosis of activated T-cells and T-leukemia cell lines and inhibits the protein phosphatase activity of CD45. Recombinant human Galectin-1 is a 14.5 kDa protein containing 134 amino acid residues. |
Human Galectin-1 Recombinant Protein |
100-175S |
ReliaTech |
10 µg |
EUR 92.4 |
Description: Lectins, of either plant or animal origin, are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. The Galectins are lectins that recognize and interact with β-galactoside moieties. Galectin-1 is an animal lectin that has been shown to interact with CD3, CD4, and CD45. It induces apoptosis of activated T-cells and T-leukemia cell lines and inhibits the protein phosphatase activity of CD45. Recombinant human Galectin-1 is a 14.5 kDa protein containing 134 amino acid residues. |
Human Galectin-1 Recombinant Protein |
400-015 |
ReliaTech |
50 µg |
EUR 126 |
Description: Lectins, of either plant or animal origin, are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. The Galectins are lectins that recognize and interact with beta-galactoside moieties. Galectin-1 is an animal lectin that has been shown to interact with CD3, CD4, and CD45. It induces apoptosis of activated T-cells and T-leukemia cell lines and inhibits the protein phosphatase activity of CD45. Recombinant human Galectin-1 is a 14.5 kDa protein containing 134 amino acid residues. |
Recombinant Human Galectin-1 Protein |
E40KMP1041 |
EnoGene |
20ug |
EUR 495 |
Rational Design of a Sturdy Antibody-Like Small Molecule Inhibitor Nanoplatform for Enhanced Photoimmunotherapy
Immune checkpoint blockade of programmed cell death-ligand 1/programmed cell death-1 (PD-L1/PD-1) pathway through antibody is a potent technique for T cells reworking. Nonetheless, the efficiency of antibody is partly compromised by its excessive value, instability, threat of autoimmune illness, and many others. Small molecule inhibitors are attention-grabbing alternate options to antibodies.
- Nonetheless, tumor-specific supply of small molecule inhibitor to the goal web site for reinforcing the interruption of PD-L1/PD-1 pathway is never reported. Herein, we designed a tumor-specific supply nanoplatform that might effectively ship the small molecule inhibitor to the exact goal web site, significantly enhancing the blocking impact of PD-L1/PD-1 pathway.
- Hyaluronic acid (HA) was conjugated with chlorin e6 (Ce6), leading to a HA-Ce6 conjugate (HC). The nanoplatform was constructed by the HC micelles with encapsulation of small molecule inhibitor BMS 202 (BMS) to kind BMS/HC micelles.
- The goal property of HA, mixed with the hyaluronidase-induced degradation of HA in tumor web site, allows the as-prepared micelles with tumor-specific supply of BMS for blocking PD-L1/PD-1 pathway.
- Cooperative remedy with the photosensitizer Ce6, the current therapeutic nanoplatform demonstrated glorious photoimmunotherapy for tumor regression in distant tumors and lung metastasis.
- This technique of tumor-specific supply of small molecule inhibitors offers an efficient pathway to strengthen the blocking efficacy of PD-L1/PD-1 on efficient photoimmunotherapy.
PE anti-human CD163 |
E16FHP163-025 |
EnoGene |
25 tests |
EUR 433.33 |
Description: Available in various conjugation types. |
PE anti-human CD163 |
E16FHP163-100 |
EnoGene |
100 tests |
EUR 953.33 |
Description: Available in various conjugation types. |
Anti-Human CD163 Antibody |
101-M291 |
ReliaTech |
100 µg |
EUR 399 |
Description: CD163, also known as hemoglobin scavenger receptor, is a type I transmembrane protein expressed exclusively in monocytes and macrophages. It is a scavenger receptor cysteine-rich superfamily (SRCR-SF) protein that contains nine SRCR motifs in its extracellular region. Two alternatively spliced cytoplasmic variants of human CD163 exist. A soluble form of CD163 can also be released by metalloproteinase-mediated shedding of the extracellular domain. CD163 mediates the endocytosis of haptoglobin-hemoglobin complexes. |
APC anti-human CD163 |
E16FHA163-025 |
EnoGene |
25 tests |
EUR 520 |
Description: Available in various conjugation types. |
APC anti-human CD163 |
E16FHA163-100 |
EnoGene |
100 tests |
EUR 1191.67 |
Description: Available in various conjugation types. |
FITC anti-human CD163 |
E16FHF163-025 |
EnoGene |
25 tests |
EUR 520 |
Description: Available in various conjugation types. |
FITC anti-human CD163 |
E16FHF163-100 |
EnoGene |
100 tests |
EUR 1191.67 |
Description: Available in various conjugation types. |
Biotin anti-human CD163 |
E16FHB163-025U |
EnoGene |
25 μg |
EUR 346.67 |
Description: Available in various conjugation types. |
Biotin anti-human CD163 |
E16FHB163-100U |
EnoGene |
100 μg |
EUR 780 |
Description: Available in various conjugation types. |
Purified anti-human CD163 |
E16FHU163-100U |
EnoGene |
100 μg |
EUR 433.33 |
Description: Available in various conjugation types. |
CD163 (GFP-tagged) - Human CD163 molecule (CD163), transcript variant 2 |
RG212754 |
Origene Technologies GmbH |
10 µg |
Ask for price |
CD163 (GFP-tagged) - Human CD163 molecule (CD163), transcript variant 1 |
RG208557 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Rabbit Anti Human CD163 Monoclonal Clone ABCC-3 |
IRBAHUCD163ABCC3C100UL |
Innovative research |
each |
EUR 496 |
|
Description: Rabbit Anti Human CD163 Monoclonal Clone ABCC-3 |
Recombinant Human CD163/CD163 Protein, His Tag |
E40KMH346 |
EnoGene |
20ug |
EUR 495 |
PE-Cy7 anti-human CD163 |
E16FHN163-025 |
EnoGene |
25 tests |
EUR 650 |
Description: Available in various conjugation types. |
PE-Cy7 anti-human CD163 |
E16FHN163-100 |
EnoGene |
100 tests |
EUR 1408.33 |
Description: Available in various conjugation types. |
APC-Cy7 anti-human CD163 |
E16FHO163-025 |
EnoGene |
25 tests |
EUR 650 |
Description: Available in various conjugation types. |
APC-Cy7 anti-human CD163 |
E16FHO163-100 |
EnoGene |
100 tests |
EUR 1408.33 |
Description: Available in various conjugation types. |
CD163 (Myc-DDK-tagged)-Human CD163 molecule (CD163), transcript variant 1 |
RC208557 |
Origene Technologies GmbH |
10 µg |
Ask for price |
CD163 (Myc-DDK-tagged)-Human CD163 molecule (CD163), transcript variant 2 |
RC212754 |
Origene Technologies GmbH |
10 µg |
Ask for price |
PerCP-Cy5.5 anti-human CD163 |
E16FHS163-025 |
EnoGene |
25 tests |
EUR 541.67 |
Description: Available in various conjugation types. |
PerCP-Cy5.5 anti-human CD163 |
E16FHS163-100 |
EnoGene |
100 tests |
EUR 1278.33 |
Description: Available in various conjugation types. |
Human CD163 Protein |
E40KMPH6242 |
EnoGene |
20ug |
EUR 495 |
anti- CD163/M130 Antibody |
FNab09771 |
FN Test |
100µg |
EUR 658.5 |
|
Description: Antibody raised against CD163/M130 |
Anti-Hu CD163 PE |
1P-645-T025 |
ExBio |
25 tests |
EUR 121 |
Anti-Hu CD163 PE |
1P-645-T100 |
ExBio |
100 tests |
EUR 242 |
|
Anti-Hu CD163 APC |
1A-645-T025 |
ExBio |
25 tests |
EUR 121 |
Anti-Hu CD163 APC |
1A-645-T100 |
ExBio |
100 tests |
EUR 242 |
|
Anti-Hu CD163 Purified |
11-645-C025 |
ExBio |
0.025 mg |
EUR 71.5 |
Anti-Hu CD163 Purified |
11-645-C100 |
ExBio |
0.1 mg |
EUR 143 |
|
Human CD163, Fc Tag |
E24PHA282 |
EnoGene |
50 μg |
EUR 250 |
Human CD163, His Tag |
E24PHA281 |
EnoGene |
50 μg |
EUR 250 |
Mouse Monoclonal anti-Human CD163 Antibody |
xAP-0134 |
Angio Proteomie |
100ug |
EUR 280 |
Mouse Monoclonal anti-Human CD163 Antibody |
xAP-0135 |
Angio Proteomie |
100ug |
EUR 280 |
Human CD163 ELISA Kit |
EK5296 |
SAB |
96 tests |
EUR 599 |
|
Human CD163 ELISA Kit |
GWB-SKR207 |
GenWay Biotech |
96 Tests |
Ask for price |
Human CD163 ELISA Kit |
LF-EK50890 |
Abfrontier |
1×96T |
EUR 777.6 |
Human CD163 shRNA Plasmid |
20-abx956176 |
Abbexa |
-
Ask for price
-
Ask for price
|
|
|
CD163 Antigen (CD163) Rabbit anti-Human Polyclonal (N-Terminus) (K20-T) Antibody |
GWB-B1E200 |
GenWay Biotech |
0.05 ml |
Ask for price |
Recombinant Human CD163 Protein |
RP02295 |
Abclonal |
500μg |
EUR 1625 |
|
PE Anti-human CD163 Antibody *GHI/61* |
116301K0 |
AAT Bioquest |
25 tests |
EUR 391 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
PE Anti-human CD163 Antibody *GHI/61* |
116301K0-25tests |
AAT Bioquest |
25 tests |
EUR 383 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
PE Anti-human CD163 Antibody *GHI/61* |
116301K1 |
AAT Bioquest |
100 tests |
EUR 1015 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
PE Anti-human CD163 Antibody *GHI/61* |
116301K1-100tests |
AAT Bioquest |
100 tests |
EUR 995 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
PE Anti-human CD163 Antibody *GHI/61* |
116301K2 |
AAT Bioquest |
500 tests |
EUR 3044 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
PE Anti-human CD163 Antibody *GHI/61* |
116301K2-500tests |
AAT Bioquest |
500 tests |
EUR 2984 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
Human CellExp? CD163, Human recombinant |
9226-10 |
Biovision |
each |
EUR 366 |
Human CellExp? CD163, Human recombinant |
9226-50 |
Biovision |
each |
EUR 927.6 |
APC Anti-human CD163 Antibody *GHI/61* |
116301B0 |
AAT Bioquest |
25 tests |
EUR 391 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
APC Anti-human CD163 Antibody *GHI/61* |
116301B0-25tests |
AAT Bioquest |
25 tests |
EUR 383 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
APC Anti-human CD163 Antibody *GHI/61* |
116301B1 |
AAT Bioquest |
100 tests |
EUR 1015 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
APC Anti-human CD163 Antibody *GHI/61* |
116301B1-100tests |
AAT Bioquest |
100 tests |
EUR 995 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
APC Anti-human CD163 Antibody *GHI/61* |
116301B2 |
AAT Bioquest |
500 tests |
EUR 3044 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
APC Anti-human CD163 Antibody *GHI/61* |
116301B2-500tests |
AAT Bioquest |
500 tests |
EUR 2984 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
Alexa Fluor® 647 anti-human CD163 |
E16FHK163-025 |
EnoGene |
25 tests |
EUR 433.33 |
Description: Available in various conjugation types. |
Alexa Fluor® 647 anti-human CD163 |
E16FHK163-100 |
EnoGene |
100 tests |
EUR 975 |
Description: Available in various conjugation types. |
FITC Anti-human CD163 Antibody *GHI/61* |
116301G0 |
AAT Bioquest |
100 tests |
EUR 558 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
FITC Anti-human CD163 Antibody *GHI/61* |
116301G0-100tests |
AAT Bioquest |
100 tests |
EUR 547 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
FITC Anti-human CD163 Antibody *GHI/61* |
116301G1 |
AAT Bioquest |
500 tests |
EUR 2093 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
FITC Anti-human CD163 Antibody *GHI/61* |
116301G1-500tests |
AAT Bioquest |
500 tests |
EUR 2051 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
TRITC Anti-human CD163 Antibody *GHI/61* |
116301H0 |
AAT Bioquest |
100 tests |
EUR 558 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
TRITC Anti-human CD163 Antibody *GHI/61* |
116301H0-100tests |
AAT Bioquest |
100 tests |
EUR 547 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
TRITC Anti-human CD163 Antibody *GHI/61* |
116301H1 |
AAT Bioquest |
500 tests |
EUR 2093 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
TRITC Anti-human CD163 Antibody *GHI/61* |
116301H1-500tests |
AAT Bioquest |
500 tests |
EUR 2051 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
PerCP Anti-human CD163 Antibody *GHI/61* |
116301S0 |
AAT Bioquest |
25 tests |
EUR 391 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
PerCP Anti-human CD163 Antibody *GHI/61* |
116301S0-25tests |
AAT Bioquest |
25 tests |
EUR 383 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
PerCP Anti-human CD163 Antibody *GHI/61* |
116301S1 |
AAT Bioquest |
100 tests |
EUR 1015 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
PerCP Anti-human CD163 Antibody *GHI/61* |
116301S1-100tests |
AAT Bioquest |
100 tests |
EUR 995 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
PerCP Anti-human CD163 Antibody *GHI/61* |
116301S2 |
AAT Bioquest |
500 tests |
EUR 3044 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
PerCP Anti-human CD163 Antibody *GHI/61* |
116301S2-500tests |
AAT Bioquest |
500 tests |
EUR 2984 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
PacBlue Anti-human CD163 Antibody *GHI/61* |
116301I0 |
AAT Bioquest |
100 tests |
EUR 558 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
PacBlue Anti-human CD163 Antibody *GHI/61* |
116301I0-100tests |
AAT Bioquest |
100 tests |
EUR 547 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |