August 24, 2020
Antibody against the CSP N-terminal domain lacks Plasmodium
A high-affinity antibody in opposition to the CSP N-terminal area lacks Plasmodium falciparum inhibitory exercise
Malaria is a world well being concern, and analysis efforts are ongoing to develop a superior vaccine to RTS,S/AS01. To information immunogen design, we search a complete understanding of the protecting humoral response in opposition to Plasmodium falciparum (Pf) circumsporozoite protein (PfCSP). In distinction to the well-studied responses to the repeat area and the C-terminus, the antibody response in opposition to the N-terminal area of PfCSP (N-CSP) stays obscure.
- Right here, we characterised the molecular recognition and practical efficacy of the N-CSP-specific monoclonal antibody 5D5.
- The crystal construction at 1.85-Å decision revealed that 5D5 binds an α-helical epitope in N-CSP with excessive affinity by means of in depth form and cost complementarity and the weird utilization of an antibody N-linked glycan.
- Nonetheless, practical research indicated low 5D5 binding to stay Pf sporozoites and lack of sporozoite inhibition in vitro and in vivo. General, our knowledge don’t assist the inclusion of the 5D5 N-CSP epitope into the following era of CSP-based vaccines.
Absence of YF-neutralizing antibodies in susceptible populations of Brazil: A warning for epidemiological surveillance and the potential dangers for future outbreaks
Yellow Fever (YF) is an acute febrile sickness brought on by yellow fever virus (YFV), a mosquito-borne flavivirus transmitted topeople and non-human primates. In Brazil, YF is a public well being risk and will trigger recurrent epidemics, even with the supply of a vaccine.
We evaluated the sero-status for YFV in 581 people dwelling in a danger space for YF in Brazil. The realm presents historical past of circumstances and is positioned within the southeast area of nation the place outbreaks of YF have been reported since 2016.
Via, a PRNT assay, we discovered 25.8% of peoplemissing YF-neutralizing antibodies. Moreover, neutralizing antibodies weren’t detected in 10 people with confirmed vaccination. Our findings reinforce the significance of surveillance methods and the necessity of an pressing intensification of immunization packages in areas with YFV circulation.
Monitoring vulnerable people that might act as potential disseminators for YFV in danger areas also needs to be thought of.
genediag
Human Neurotensin (NT) ELISA Kit |
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| RD-NT-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 830.4 |
Human Neurotensin (NT) ELISA Kit |
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| RDR-NT-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 626.4 |
Human Neurotensin (NT) ELISA Kit |
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| RDR-NT-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 868.8 |
Nitrotyrosine (NT) ELISA Kit |
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| DLR-NT-Ge-48T | DL Develop | 48T | EUR 690 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Nitrotyrosine (NT) in samples from serum, plasma, tissue homogenates or other biological fluids. |
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Nitrotyrosine (NT) ELISA Kit |
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| DLR-NT-Ge-96T | DL Develop | 96T | EUR 903.6 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Nitrotyrosine (NT) in samples from serum, plasma, tissue homogenates or other biological fluids. |
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Rabbit Polyclonal antibody Anti-CRBN |
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| Anti-CRBN | ImmunoStep | 50 µg | EUR 418.8 |
Anti-NT-3 antibody |
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| STJ98718 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: NT-3 is a protein encoded by the NTF3 gene which is approximately 29,4 kDa. NT-3 is secreted and is involved in apoptotic pathways in synovial fibroblasts, the GPCR pathway, ERK signalling, TGF-beta pathway and nanog in mammalian ESC pluripotency. This protein falls under the neurotrophin family. It controls survival and differentiation of mammalian neurons and is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo. NT-3 is expressed in the brain and peripheral tissues. Mutations in the NTF3 gene result in diabetic neuropathy and pediatric fibrosarcoma. STJ98718 was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. This polyclonal antibody binds to endogenous NT-3. |
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Rat Neurotensin (NT) ELISA Kit |
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| DLR-NT-Ra-48T | DL Develop | 48T | EUR 633.6 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Rat Neurotensin (NT) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Rat Neurotensin (NT) ELISA Kit |
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| DLR-NT-Ra-96T | DL Develop | 96T | EUR 828 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Rat Neurotensin (NT) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Rat Neurotensin (NT) ELISA Kit |
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| RD-NT-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 640.8 |
Rat Neurotensin (NT) ELISA Kit |
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| RD-NT-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 890.4 |
General Nitrotyrosine (NT) ELISA Kit |
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| RDR-NT-Ge-48Tests | Reddot Biotech | 48 Tests | EUR 735.6 |
General Nitrotyrosine (NT) ELISA Kit |
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| RDR-NT-Ge-96Tests | Reddot Biotech | 96 Tests | EUR 1024.8 |
Rat Neurotensin (NT) ELISA Kit |
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| RDR-NT-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 669.6 |
Rat Neurotensin (NT) ELISA Kit |
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| RDR-NT-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 931.2 |
NT-3 |
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| GT15000 | Neuromics | 100 ug | EUR 631.2 |
NT-3 |
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| GT15128 | Neuromics | 100 ug | EUR 600 |
Anti-NT Antibody |
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| A03097 | BosterBio | 100ul | EUR 476.4 |
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Description: Rabbit Polyclonal NT Antibody. Validated in WB and tested in Human. |
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NT-3, human recombinant |
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| 4306-10 | Biovision | each | EUR 320.4 |
NT-3, human recombinant |
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| 4306-1000 | Biovision | each | EUR 6434.4 |
NT-3, human recombinant |
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| 4306-50 | Biovision | each | EUR 874.8 |
NT-3/ Rat NT- 3 ELISA Kit |
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| ELA-E0106r | Lifescience Market | 96 Tests | EUR 1063.2 |
Anti-SUMO-2/3 (NT) Antibody |
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| A01282 | BosterBio | 100ul/vial | EUR 530.4 |
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Description: Rabbit Polyclonal SUMO-2/3 (NT) Antibody. Validated in WB and tested in Human. |
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Nitrotyrosine (NT/3-NT) CLIA Kit |
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| 20-abx490435 | Abbexa |
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Polyclonal Goat anti-GST α-form |
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| GST-ANTI-1 | Detroit R&D | 50 uL | EUR 336 |
Polyclonal Goat anti-GST μ-form |
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| GST-ANTI-2 | Detroit R&D | 50 uL | EUR 336 |
rHu NT-3 |
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| AK8543-0002 | Akron Biotech | 2µg | Ask for price |
rHu NT-3 |
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| AK8543-0010 | Akron Biotech | 10µg | Ask for price |
rHu NT-3 |
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| AK8543-0100 | Akron Biotech | 100µg | Ask for price |
rHu NT-3 |
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| AK8543-1000 | Akron Biotech | 1mg | Ask for price |
NT-3 Antibody |
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| 5306-200 | Biovision | each | EUR 379.2 |
NT-3 Antibody |
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| 5306-30T | Biovision | each | EUR 175.2 |
Anti-VEGF Receptor 3/FLT4 Antibody |
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| A01276-3 | BosterBio | 100ug/vial | EUR 400.8 |
Anti-14-3-3 alpha + beta Rabbit Monoclonal Antibody |
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| M02431-3 | BosterBio | 100ug/vial | EUR 476.4 |
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Description: Rabbit Monoclonal 14-3-3 alpha + beta Antibody. Validated in Flow Cytometry, IP, IF, IHC, ICC, WB and tested in Human, Mouse, Rat. |
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Human N-Terminal Pro Atrial Natriuretic Peptide (NT-ProANP) ELISA Kit |
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| DLR-NT-ProANP-Hu-48T | DL Develop | 48T | EUR 574.8 |
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Description: A sandwich quantitative ELISA assay kit for detection of Human N-Terminal Pro Atrial Natriuretic Peptide (NT-ProANP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Human N-Terminal Pro Atrial Natriuretic Peptide (NT-ProANP) ELISA Kit |
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| DLR-NT-ProANP-Hu-96T | DL Develop | 96T | EUR 745.2 |
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Description: A sandwich quantitative ELISA assay kit for detection of Human N-Terminal Pro Atrial Natriuretic Peptide (NT-ProANP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Human N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) ELISA Kit |
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| DLR-NT-ProBNP-Hu-48T | DL Develop | 48T | EUR 484.8 |
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Description: A sandwich quantitative ELISA assay kit for detection of Human N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Human N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) ELISA Kit |
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| DLR-NT-ProBNP-Hu-96T | DL Develop | 96T | EUR 621.6 |
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Description: A sandwich quantitative ELISA assay kit for detection of Human N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Human N-Terminal Pro Atrial Natriuretic Peptide (NT-ProANP) ELISA Kit |
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| RD-NT-ProANP-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 573.6 |
Human N-Terminal Pro Atrial Natriuretic Peptide (NT-ProANP) ELISA Kit |
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| RD-NT-ProANP-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 794.4 |
Human N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) ELISA Kit |
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| RD-NT-ProBNP-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 471.6 |
Human N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) ELISA Kit |
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| RD-NT-ProBNP-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 649.2 |
Human N-Terminal Pro Atrial Natriuretic Peptide (NT-ProANP) ELISA Kit |
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| RDR-NT-ProANP-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 600 |
Human N-Terminal Pro Atrial Natriuretic Peptide (NT-ProANP) ELISA Kit |
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| RDR-NT-ProANP-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 830.4 |
Human N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) ELISA Kit |
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| RDR-NT-ProBNP-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 493.2 |
Human N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) ELISA Kit |
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| RDR-NT-ProBNP-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 678 |
Anti-BACE2 (NT) Antibody |
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| A02963 | BosterBio | 100ug | EUR 579.6 |
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Description: Rabbit Polyclonal BACE2 (NT) Antibody. Validated in IHC, WB and tested in Human, Mouse, Rat. |
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Anti-PHAP (NT) Antibody |
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| A03625 | BosterBio | 100ug | EUR 565.2 |
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Description: Rabbit Polyclonal PHAP (NT) Antibody. Validated in WB and tested in Human, Mouse, Rat. |
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Anti-NT-4 Antibody |
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| A06935-2 | BosterBio | 100ul | EUR 476.4 |
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Description: Rabbit Polyclonal NT-4 Antibody. Validated in IHC and tested in Human, Mouse, Rat. |
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Anti-CX3CR1 (NT) Antibody |
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| A00280 | BosterBio | 100ug | EUR 565.2 |
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Description: Rabbit Polyclonal CX3CR1 (NT) Antibody. Validated in IHC, WB and tested in Human, Mouse, Rat. |
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anti- NT-proBNP antibody |
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| FNab10151 | FN Test | 100µg | EUR 658.5 |
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Description: Antibody raised against NT-proBNP |
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Anti-NT-4 antibody |
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| STJ94562 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: Rabbit polyclonal to NT-4. |
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Anti-NT-proBNP antibody |
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| STJ400145 | St John's Laboratory | 1 mg | EUR 535.2 |
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Description: The plasma concentrations of both the N-terminal fragment of Pro-B-type natriuretic peptide (NT-proBNP) and prohormone of brain natriuretic peptide (proBNP) are significantly increased in patients with asymptomatic and symptomatic left ventricular dysfunction. |
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Anti-NT-proBNP antibody |
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| STJ400146 | St John's Laboratory | 1 mg | EUR 535.2 |
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Description: The plasma concentrations of both the N-terminal fragment of Pro-B-type natriuretic peptide (NT-proBNP) and prohormone of brain natriuretic peptide (proBNP) are significantly increased in patients with asymptomatic and symptomatic left ventricular dysfunction. |
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Anti-Human IBA1 Antibody |
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| M01394-3 | BosterBio | 100ul | EUR 476.4 |
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Description: Chicken Polyclonal Human IBA1 Antibody. Validated in IF, IHC, WB and tested in Human. |
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Anti-Human Ki67 Antibody |
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| M00254-3 | BosterBio | 100ul | EUR 476.4 |
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Description: Rabbit Polyclonal Human Ki67 Antibody. Validated in IHC, WB and tested in Human, Mouse, Rat. |
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Human 3-NT ELISA Kit |
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| EHA0677 | Abclonal | 96Tests | EUR 625.2 |
Human NT-3 ELISA Kit |
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| EHN0025 | Abclonal | 96Tests | EUR 625.2 |
NT-3 ELISA KIT|Human |
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| EF000198 | Lifescience Market | 96 Tests | EUR 826.8 |
Human NT-3 ELISA kit |
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| LF-EK50297 | Abfrontier | 1×96T | EUR 777.6 |
Recombinant Human NT-3 Protein |
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| PROTP20783-1 | BosterBio | 10ug | EUR 380.4 |
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Description: NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous systems and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, murine and rat NT-3 are identical. Recombinant human NT-3 is a noncovalently linked homodimer, of two 13.6 kDa polypeptide monomers (240 total amino acid residues). Human and Mouse NT-3 sequences are identical. |
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Anti-active Caspase-3 Rabbit Monoclonal Antibody |
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| M00334-3 | BosterBio | 100ug/vial | EUR 476.4 |
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Description: Anti-active Caspase-3 Rabbit Monoclonal Antibody tested for IF, IHC, ICC, WB in Human |
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Anti-Galectin 3/LGALS3 Antibody (monoclonal, 12B12) |
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| M00621-3 | BosterBio | 100ug/vial | EUR 400.8 |
Human N-Terminal Pro C-Type Natriuretic Peptide (NT-ProCNP) ELISA Kit |
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| DLR-NT-ProCNP-Hu-48T | DL Develop | 48T | EUR 620.4 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Human N-Terminal Pro C-Type Natriuretic Peptide (NT-ProCNP) in samples from serum, plasma, tissue homogenates or other biological fluids. |
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Human N-Terminal Pro C-Type Natriuretic Peptide (NT-ProCNP) ELISA Kit |
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| DLR-NT-ProCNP-Hu-96T | DL Develop | 96T | EUR 807.6 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Human N-Terminal Pro C-Type Natriuretic Peptide (NT-ProCNP) in samples from serum, plasma, tissue homogenates or other biological fluids. |
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Human N-Terminal Pro C-Type Natriuretic Peptide (NT-ProCNP) ELISA Kit |
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| RD-NT-ProCNP-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 625.2 |
Human N-Terminal Pro C-Type Natriuretic Peptide (NT-ProCNP) ELISA Kit |
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| RD-NT-ProCNP-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 867.6 |
Human N-Terminal Pro C-Type Natriuretic Peptide (NT-ProCNP) ELISA Kit |
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| RDR-NT-ProCNP-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 652.8 |
Human N-Terminal Pro C-Type Natriuretic Peptide (NT-ProCNP) ELISA Kit |
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| RDR-NT-ProCNP-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 907.2 |
Anti-Glyceraldehyde 3-Phosphate Dehydrogenase [GAPDH] Monoclonal Antibody |
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| M00227-3 | BosterBio | 100ul | EUR 476.4 |
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Description: Mouse Monoclonal Glyceraldehyde 3-Phosphate Dehydrogenase [GAPDH] Antibody. Validated in IHC, WB and tested in Equine. |
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Recombinant Transmembrane Protease Serine 2 Protein, Partial |
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| E80016 | EpiGentek |
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Recombinant TMPRSS2 Protein, Partial |
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| E80017 | EpiGentek |
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Recombinant Novel Coronavirus Spike Glycoprotein(S), Partial |
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| E80018 | EpiGentek |
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Human NT-proBNP/ NT-proBNP ELISA Kit |
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| E1806Hu | Sunlong | 1 Kit | EUR 685.2 |
NT-4, Human |
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| HY-P7272 | MedChemExpress | 50ug | EUR 914.4 |
NT-4 (human) |
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| GT15001 | Neuromics | 100 ug | EUR 631.2 |
Human Neurotrophin-3 (NT-3) CLIA Kit |
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| abx196112-96tests | Abbexa | 96 tests | EUR 990 |
Human Neurotrophin-3,NT-3 ELISA KIT |
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| 201-12-1306 | SunredBio | 96 tests | EUR 528 |
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Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
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Human 3-Nitrotyrosine,3-NT ELISA Kit |
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| 201-12-1426 | SunredBio | 96 tests | EUR 528 |
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Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
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Human Neurotrophin-3, NT-3 ELISA KIT |
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| CSB-E04686h-24T | Cusabio | 1 plate of 24 wells | EUR 198 |
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Description: Quantitativesandwich ELISA kit for measuring Human Neurotrophin-3, NT-3 in samples from serum, plasma, cell culture supernates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
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Human Neurotrophin-3, NT-3 ELISA KIT |
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| 1-CSB-E04686h | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Human Neurotrophin-3, NT-3 in samples from serum, plasma, cell culture supernates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
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Human 3-nitrotyrosine (3-NT) ELISA Kit |
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| CSB-E14324h-24T | Cusabio | 1 plate of 24 wells | EUR 198 |
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Description: Quantitativesandwich ELISA kit for measuring Human 3-nitrotyrosine (3-NT) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
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Human 3-nitrotyrosine (3-NT) ELISA Kit |
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| 1-CSB-E14324h | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Human 3-nitrotyrosine (3-NT) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
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Human Neurotrophin-3,NT-3 ELISA KIT |
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| CN-03259H1 | ChemNorm | 96T | EUR 525.6 |
Human Neurotrophin-3,NT-3 ELISA KIT |
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| CN-03259H2 | ChemNorm | 48T | EUR 346.8 |
Human NT-3(Neurotrophin-3) ELISA Kit |
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| EH0245 | FN Test | 96T | EUR 628.92 |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml |
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Human Neurotrophin-3(NT-3)ELISA Kit |
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| GA-E1322HM-48T | GenAsia Biotech | 48T | EUR 346.8 |
Human Neurotrophin-3(NT-3)ELISA Kit |
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| GA-E1322HM-96T | GenAsia Biotech | 96T | EUR 559.2 |
Human 3-Nitrotyrosine(3-NT)ELISA Kit |
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| GA-E1442HM-48T | GenAsia Biotech | 48T | EUR 346.8 |
Human 3-Nitrotyrosine(3-NT)ELISA Kit |
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| GA-E1442HM-96T | GenAsia Biotech | 96T | EUR 559.2 |
NT-3 Neurotrophin-3 Human Recombinant Protein |
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| PROTP20783 | BosterBio | Regular: 10ug | EUR 380.4 |
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Description: Neurotrophin-3 Human Recombinant produced in E.Coli is a non-glycosylated and non-covalently linked homodimer, containing 2x119 amino acid chains, having a total Mw of 27.2 kDa.;The NT-3 is purified by proprietary chromatographic techniques. |
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Recombinant Human NT-3/Neurotrophin-3 Protein |
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| RP00496 | Abclonal | 10 μg | EUR 265.2 |
Human Neurotrophin-3(NT-3)ELISA Kit |
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| QY-E01634 | Qayee Biotechnology | 96T | EUR 433.2 |
Human 3-Nitrotyrosine(3-NT)ELISA Kit |
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| QY-E05212 | Qayee Biotechnology | 96T | EUR 433.2 |
Human Neurotrophin-3,NT-3 ELISA KIT |
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| YLA1770HU-48T | Shanghai YL Biotech | 48T | EUR 435 |
Human Neurotrophin-3,NT-3 ELISA KIT |
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| YLA1770HU-96T | Shanghai YL Biotech | 96T | EUR 562.5 |
Human 3-Nitrotyrosine,3-NT ELISA Kit |
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| YLA1788HU-48T | Shanghai YL Biotech | 48T | EUR 435 |
Molecular and structural foundation for Lewis glycan recognition by a cancer-targeting antibody
Immunotherapy has been profitable in treating many tumour sorts. The event of extra tumour-antigen binding monoclonal antibodies (mAbs) will assist develop the vary of immunotherapeutic targets. Lewis histo-blood group and associated glycans are overexpressed on many carcinomas, together with these of the colon, lung, breast, prostate and ovary, and might due to this fact be selectively focused by mAbs.
- Right here we look at the molecular and structural foundation for recognition of prolonged Lea and Lexcontaining glycans by a chimeric mAb. Each the murine (FG88.2) IgG3 and a chimeric (ch88.2) IgG1 mAb variants confirmed reactivity to colorectal most cancers cells resulting in considerably decreased cell viability.
- We decided the X-ray construction of the unliganded ch88.2 fragment antigen-binding (Fab) containing two Fabs within the unit cell. A mix of molecular docking, glycan grafting and molecular dynamics simulations predicts two distinct subsites for recognition of Lea and Lex trisaccharides.
- Whereas gentle chain residues have been completely used for Lea binding, recognition of Lex concerned each gentle and heavy chain residues. An prolonged groove is predicted to accommodate the Lea-Lex hexasaccharide with adjoining subsites for every trisaccharide.
- The molecular and structural particulars of the ch88.2 mAb offered right here present perception into its cross-reactivity for varied Lea and Lexcontaining glycans. Moreover, the anticipated interactions with prolonged epitopes seemingly explains the selectivity of this antibody for concentrating on Lewis-positive tumours.
Dynamic modifications of throat swabs RNA and serum antibodies for SARS-CoV-2 and their diagnostic performances in sufferers with COVID-19
Dynamic modifications of RNA and antibodies in SARS-CoV-2 contaminated sufferers stay largely unknown, and affect components for antibody manufacturing haven’t been totally clarified. On this research, we enrolled 475 circumstances of COVID-19 and 389 controls. Consecutive throat swabs specimens (n=1875) from 187 sufferers have been collected to analyzed the dynamic modifications of RNA. Furthermore, 162 serial serum samples from 31 sufferers have been examined for seroconversion of IgM and IgG.
In the meantime, IgM and IgG have been additionally detected in 409 COVID-19 sufferers and 389 controls. Moreover, the logistic regression evaluation was executed to establish the attainable affect components for antibody manufacturing. The median constructive conversion time for RNA was day 7 (IQR, 3-11), and the constructive price was the very best within the early stage (74.59 % at day 1-5) after which regularly decreased. The median time of seroconversion for IgM and IgG have been each day 12 (IQR, 10-15).
The sensitivity and specificity for IgM (or IgG) was 87.04 % and 96.92 %, respectively. The constructive charges of IgM and IgG have been each low on the day 1-5 (18.52% for IgM, 14.81% for IgG), after which considerably elevated. Multivariate logistic regression indicated that decreased lymphocytes and quick constructive conversion time for SARS-CoV-2 RNA have been unbiased components for unfavourable outcomes of IgM and IgG assessments. In conclusion, dynamic modifications of RNA, IgM and IgG in opposition to SARS-CoV-2, particularly antibodies, have been distinctive and they need to be mixed for COVID-19 analysis. And antibodies seroconversion was influenced by the decreased lymphocytes and quick constructive conversion time for RNA.
anti- IL-4 antibody |
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| FNab09861 | FN Test | 100µg | EUR 658.5 |
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Description: Antibody raised against IL-4 |
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Anti-IL-4 antibody |
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| PAab04278 | Lifescience Market | 100 ug | EUR 494.4 |
Anti-IL-4 antibody |
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| STJ96510 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: Rabbit polyclonal to IL-4. |
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Anti-IL-4 antibody |
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| STJ93699 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: Rabbit polyclonal to IL-4. |
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Anti-IL-4 antibody |
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| STJ93700 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: Rabbit polyclonal to IL-4. |
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Rabbit Polyclonal antibody Anti-CRBN |
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| Anti-CRBN | ImmunoStep | 50 µg | EUR 418.8 |
Recombinant Human IL-17F Protein |
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| PROTQ96PD4-4 | BosterBio | 25ug | EUR 380.4 |
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Description: IL-17F, a member of the IL-17 family of structurally related cytokines, has been shown to stimulate proliferation and activation of T-cells and PBMCs. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis. Recombinant human IL-17F is a disulfide-linked homodimer of 30.1 kDa, consisting of two 133 amino acid residue chains. |
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Recombinant Human IL-6 Protein |
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| PROTP05231-4 | BosterBio | 20ug | EUR 380.4 |
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Description: IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant human IL-6 is a 20.9 kDa protein containing 184 amino acid residues. |
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Recombinant Human IL-3 Protein |
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| PROTP08700-4 | BosterBio | 10ug | EUR 380.4 |
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Description: IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoieses, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is species-specific, variably glycosylated cytokine. Recombinant human IL-3 is a 15.0 kDa globular protein containing 133 amino acid residues. |
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Recombinant Human IL-2 Protein |
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| PROTP60568-4 | BosterBio | 50ug | EUR 380.4 |
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Description: IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant human IL-2 is a 15.5 kDa protein, containing 134 amino acid residues including one intrachain disulfide bond. |
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mAb mouse anti-human IL-4 |
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| CT253 | U-CyTech | 0.5 mg | EUR 312 |
Recombinant Human IL-12 p80 Protein |
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| PROTP29460-4 | BosterBio | 10ug | EUR 380.4 |
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Description: IL-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicate that p40 secretion precedes that of IL-12 expression. In addition, to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23, or can form a homodimer designated as IL-12 p80. Elevated levels of IL-12 p80 are correlated with macrophage recruitment and increased inflammation in asthma and respiratory viral infection models. Recombinant human IL-12 p80 is an 80.0 kDa disulfide linked homodimer consisting of two p40 chains of IL-12. |
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Recombinant Human IL-13 Variant Protein |
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| PROTP35225-4 | BosterBio | 10ug | EUR 380.4 |
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Description: IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. A variant of IL-13 shows enhanced functional activity compared with the wild type IL-13. PeproTech's genetic variant, termed human IL-13 analog, is a mature 114 amino acid protein with a substitution of Q for R at position 112. |
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Human Interleukin-4 (IL-4) |
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| 1-CSB-EP011659HU | Cusabio |
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Description: Recombinant Human Interleukin-4(IL-4) expressed in E.coli |
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IL-4, Interleukin-4, human |
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| RC212-15 | Bio Basic | 5ug | EUR 125.26 |
Anti-mouse IL-4 antibody |
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| STJ15100035 | St John's Laboratory | 250 µg | EUR 403.2 |
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Description: This monoclonal antibody enables sensitive and specific detection of mouse IL-4 in immunoassays such as ELISA and ELISpot. |
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Anti-mouse IL-4 antibody |
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| STJ15100036 | St John's Laboratory | 500 µg | EUR 632.4 |
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Description: This monoclonal antibody is recommended for neutralization of mouse IL-4 bioactivity. |
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Anti-mouse IL-4 antibody |
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| STJ15100037 | St John's Laboratory | 250 µg | EUR 440.4 |
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Description: This monoclonal antibody enables sensitive and specific detection of mouse IL-4 in immunoassays such as ELISA and ELISpot. |
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Anti-IL-4 alpha antibody |
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| STJ97665 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: Rabbit polyclonal to IL-4Ralpha. |
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Anti-IL-4 alpha antibody |
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| STJ93702 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: Rabbit polyclonal to IL-4Ralpha. |
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Anti-IL-4 alpha antibody |
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| STJ93703 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: Rabbit polyclonal to IL-4Ralpha. |
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Recombinant Human IL-16 (129 a.a.) Protein |
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| PROTQ14005-4 | BosterBio | 10ug | EUR 380.4 |
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Description: IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, hIL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4 + T cells. Human and murine IL-16 show significant cross-species reactivity. Recombinant human IL-16 is a 13.5 kDa protein consisting of 130 amino acid residues. |
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IL-4 |
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| E13-015-1 | EnoGene | 10μg | EUR 193.2 |
IL-4 |
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| E13-015-2 | EnoGene | 50μg | EUR 606 |
IL-4 |
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| MO15071 | Neuromics | 500 ug | EUR 1092 |
IL-4 |
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| E21-050 | EnoGene | 10ug | EUR 411.6 |
IL-4 |
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| E21-D03 | EnoGene | 10ug | EUR 411.6 |
IL-4 |
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| E21-K15 | EnoGene | 10ug | EUR 411.6 |
pAb rabbit anti-human IL-4 receptor |
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| CT248 | U-CyTech | 0.5 mg | EUR 220.8 |
Recombinant Human IL-8 (72 a.a.) (CXCL8) Protein |
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| PROTP10145-4 | BosterBio | 25ug | EUR 380.4 |
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Description: IL-8 is a proinflammatory CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. It is secreted by monocytes and endothelial cells. IL-8 chemoattracts and activates neutrophils. Recombinant human IL-8 (monocyte-derived) is an 8.4 kDa protein containing 72 amino acid residues. |
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Human IL-4 Protein |
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| abx060798-20ug | Abbexa | 20 ug | EUR 560.4 |
Recombinant Human IL-4 |
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| P0052 | FN Test | 100ug | EUR 626.83 |
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Description: Recombinant Human protein for IL-4 |
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rec IL-4 (human) |
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| H-9630.0002 | Bachem | 2.0µg | EUR 313.2 |
rec IL-4 (human) |
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| H-9630.0010 | Bachem | 10.0µg | EUR 1140 |
Recombinant Human IL-4 |
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| SJB02-03 | Amyotop | 10µg/vial | EUR 342 |
Recombinant Human IL-4 |
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| SJB02-05 | Amyotop | 100µg/vial | EUR 864 |
Recombinant Human IL-4 |
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| SJB02-06 | Amyotop | 30µg/vial | EUR 516 |
IL-4, human recombinant |
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| 4137-10 | Biovision | each | EUR 333.6 |
IL-4, human recombinant |
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| 4137-1000 | Biovision | each | EUR 4444.8 |
IL-4, human recombinant |
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| 4137-50 | Biovision | each | EUR 836.4 |
Interleukin-4/IL-4 |
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| E21-K74 | EnoGene | 10ug | EUR 411.6 |
Human Interleukin-4 (IL-4) Antibody |
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| 32184-05111 | AssayPro | 150 ug | EUR 313.2 |
Swine IL-10 Recombinant Protein |
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| R00021-4 | BosterBio | 5ug/vial | EUR 310.8 |
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Description: IL-10 is an anti-inflammatory cytokine and a member of the IL-10 family of cytokines, which have indispensable functions in many infectious and inflammatory diseases. Swine IL-10 Recombinant Protein is purified interleukin-10 produced in yeast. |
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Mouse IL-13 Recombinant Protein |
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| R00077-4 | BosterBio | 5ug/vial | EUR 310.8 |
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Description: IL-13 is an important mediator of allergic inflammation and disease. In addition to effects on immune cells, IL-13 is implicated as a central mediator of the physiologic changes induced by allergic inflammation in many tissues. Mouse IL-13 Recombinant Protein is purified interleukin-13 produced in yeast. |
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Feline IL-6 Recombinant Protein |
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| R00102-4 | BosterBio | 5ug/vial | EUR 310.8 |
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Description: Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. Feline IL-6 Recombinant Protein is purified interleukin-6 produced in yeast. |
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Feline IL-2 Recombinant Protein |
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| R00387-4 | BosterBio | 5ug/vial | EUR 310.8 |
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Description: Interleukin-2 (IL-2) is a cytokine produced by T-helper cells in response to antigenic or mitogenic stimulation. It is required for T-cell proliferation and other activities crucial to the regulation of the immune response. Feline IL-2 Recombinant Protein is purified interleukin-2 produced in yeast. |
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Mouse IL-17A Recombinant Protein |
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| R00421-4 | BosterBio | 5ug/vial | EUR 310.8 |
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Description: IL-17A is a member of the IL-17 family of cytokines, whose members are involved in numerous immune regulatory functions. IL-17 induces the production of many other cytokines, chemokines, and prostaglandins. Mouse IL-17A Recombinant Protein is purified interleukin-17A produced in yeast. |
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Dolphin IL-8 Recombinant Protein |
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| R00423-4 | BosterBio | 5ug/vial | EUR 310.8 |
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Description: Interleukin-8 (IL-8), also known as CXCL8, is an ELR-positive CXC family member chemokine produced by macrophages and other cell types such as epithelial cells. ELR-positive CXC chemokines such as IL-8 specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2. Dolphin IL-8 Recombinant Protein is purified interleukin-8 produced in yeast. |
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Swine IL-21 Recombinant Protein |
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| R00459-4 | BosterBio | 5ug/vial | EUR 310.8 |
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Description: The cytokine interleukin-21 (IL-21) regulates the proliferation and differentiation of T and B lymphocytes, modulates the cytotoxic activity and survival of NK and CD8+ T cells, and suppresses the maturation of dendritic cells. Swine IL-21 Recombinant Protein is purified interleukin-21 produced in yeast. |
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Equine IL-1ra Recombinant Protein |
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| R00651-4 | BosterBio | 5ug/vial | EUR 310.8 |
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Description: Interleukin-1 Receptor Antagonist Protein (IL-1F3, IL-1ra) belongs to the IL-1 family of cytokines, whose members play key roles in the development and regulation of inflammation. IL-1 receptor antagonist (IL-1ra; IL-1F3) reduces inflammation by blocking the binding of the agonist receptor ligands. Equine IL-1 Receptor Antagonist Recombinant Protein is purified interleukin-1 receptor antagonist protein (IL-1F3, IL-1ra) produced in yeast. |
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IL-7 Interleukin-7 Human Recombinant Protein, His Tag |
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| PROTP13232-4 | BosterBio | Regular: 10ug | EUR 380.4 |
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Description: IL-7 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 152 amino acids fragment (26-177) and having a total molecular mass of 21.97 kDa with an amino-terminal hexahistidine tag. ;The IL-7 His-Tag protein is purified by proprietary chromatographic techniques. |
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mAb mouse anti-rat IL-4 |
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| CT028 | U-CyTech | 0.5 mg | EUR 312 |
mAb mouse anti-rat IL-4 |
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| CT029 | U-CyTech | 0.5 mg | EUR 312 |
pAb rabbit anti-rat IL-4 |
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| CT058 | U-CyTech | 0.5 mg | EUR 220.8 |
mAb mouse anti-monkey IL-4 |
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| CT103 | U-CyTech | 0.5 mg | EUR 312 |
mAb rat anti-mouse IL-4 |
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| CT324 | U-CyTech | 0.5 mg | EUR 312 |
mAb rat anti-mouse IL-4 |
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| CT337 | U-CyTech | 0.5 mg | EUR 312 |
Human High Sensitive Interleukin IL-4,IL-4 ELISA Kit |
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| YLA4123HU-48T | Shanghai YL Biotech | 48T | EUR 435 |
Human High Sensitive Interleukin IL-4,IL-4 ELISA Kit |
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| YLA4123HU-96T | Shanghai YL Biotech | 96T | EUR 562.5 |
Human FibrOut 4, for brain, neural |
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| 4-21552 | CHI Scientific | 1 ml | Ask for price |
Human FibrOut 4, for brain, neural |
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| 4-21553 | CHI Scientific | 5 x 1 ml | Ask for price |
Recombinant Human 4-1BB Receptor Protein |
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| PROTQ07011-4 | BosterBio | 20ug | EUR 380.4 |
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Description: 4-1BB Receptor, a member of the TNF superfamily of receptors, is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory signal for T lymphocytes. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells. The human 4-1BB Receptor gene codes for a 255 amino acid type I transmembrane protein containing a 17 amino acid N-terminal signal sequence, a 169 amino acid extracellular domain, a 27 amino acid transmembrane domain and a 42 amino acid cytoplasmic domain. Recombinant human soluble 4-1BB Receptor is a 167 amino acid polypeptide (17.7 kDa), which contains the cysteine rich TNFR-like extracellular domain of 4-1BB Receptor. |
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Recombinant Human PF-4 (CXCL4) Protein |
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| PROTP02776-4 | BosterBio | 20ug | EUR 380.4 |
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Description: PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the α-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis. Recombinant human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines. |
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Feline IL-1 beta Recombinant Protein |
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| R00101-4 | BosterBio | 5ug/vial | EUR 310.8 |
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Description: IL-1 beta (IL-1β) is a member of the interleukin 1 family of cytokines. The IL-1 beta cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. Feline IL-1 beta Recombinant Protein is purified interleukin-1 beta cytokine produced in yeast. |
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Feline IL-1 alpha Recombinant Protein |
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| R01144-4 | BosterBio | 5ug/vial | EUR 310.8 |
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Description: IL-1 alpha (IL-1α, IL-1F1) is a member of the interleukin 1 family of cytokines. IL-1 alpha is an inflammatory cytokine active in the initiation of the inflammatory reaction and in driving Th1 and Th17 inflammatory responses. Feline IL-1 alpha Recombinant Protein is purified interleukin-1 alpha cytokine produced in yeast. |
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rHu IL-4 |
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| AK8329-0005 | Akron Biotech | 5µg | Ask for price |
rHu IL-4 |
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| AK8329-0020 | Akron Biotech | 20µg | Ask for price |
rHu IL-4 |
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| AK8329-0100 | Akron Biotech | 100µg | Ask for price |
rHu IL-4 |
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| AK8329-1000 | Akron Biotech | 1mg | Ask for price |
IL-4 antigen |
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| E6IE600107 | EnoGene | 20ug | EUR 411.6 |
IL-4 antigen |
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| E6L00107 | EnoGene | 20ug | EUR 458.4 |
IL-4 antibody |
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| PAab09861 | Lifescience Market | 100 ug | EUR 463.2 |
IL-4 Antibody |
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| R30605 | NSJ Bioreagents | 100 ug | EUR 419 |
IL-4 Antibody |
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| R30841 | NSJ Bioreagents | 100 ug | EUR 419 |
IL-4 Antibody |
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| RQ4162 | NSJ Bioreagents | 100 ug | EUR 419 |
IL-4 Antibody |
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| RQ5106 | NSJ Bioreagents | 100ul | EUR 419 |
IL-4 Antibody |
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| V7884-100UG | NSJ Bioreagents | 100 ug | EUR 499 |
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Description: Interleukin-4 (IL-4), also designated B cell stimulatory factor-1, is a glycosylated cytokine secreted by activated T lymphocytes, basophils and mast cells. The secreted IL-4 protein promotes the growth and differentiation of cells that participate in immune defense by favoring such events as the expansion of the Th2 lineage relative to Th1 cells. These T helper cell subsets are defined by their pattern of cytokine secretion: Th1 cells secrete IL-2, TNF, while Th2 cells secrete IL-4, IL-5 and IL-10. Another key immunological function of IL-4 is to induce immunoglobulin class switching. IL-4 has been shown to induce the production of IgE and enhance IgG4 secretion by B cells, but suppress the production of IgM, IgA, IgG1, IgG2 and IgG3. It has been determined that Stat6 is rapidly tyrosine phosphorylated following stimulation of IL-3 or IL-4, but is not detectably phosphorylated following stimulation with IL-2, IL-12 or erythropoietin. |
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IL-4 Antibody |
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| V7884-20UG | NSJ Bioreagents | 20 ug | EUR 219 |
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Description: Interleukin-4 (IL-4), also designated B cell stimulatory factor-1, is a glycosylated cytokine secreted by activated T lymphocytes, basophils and mast cells. The secreted IL-4 protein promotes the growth and differentiation of cells that participate in immune defense by favoring such events as the expansion of the Th2 lineage relative to Th1 cells. These T helper cell subsets are defined by their pattern of cytokine secretion: Th1 cells secrete IL-2, TNF, while Th2 cells secrete IL-4, IL-5 and IL-10. Another key immunological function of IL-4 is to induce immunoglobulin class switching. IL-4 has been shown to induce the production of IgE and enhance IgG4 secretion by B cells, but suppress the production of IgM, IgA, IgG1, IgG2 and IgG3. It has been determined that Stat6 is rapidly tyrosine phosphorylated following stimulation of IL-3 or IL-4, but is not detectably phosphorylated following stimulation with IL-2, IL-12 or erythropoietin. |
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IL-4 Antibody |
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| V7884SAF-100UG | NSJ Bioreagents | 100 ug | EUR 499 |
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Description: Interleukin-4 (IL-4), also designated B cell stimulatory factor-1, is a glycosylated cytokine secreted by activated T lymphocytes, basophils and mast cells. The secreted IL-4 protein promotes the growth and differentiation of cells that participate in immune defense by favoring such events as the expansion of the Th2 lineage relative to Th1 cells. These T helper cell subsets are defined by their pattern of cytokine secretion: Th1 cells secrete IL-2, TNF, while Th2 cells secrete IL-4, IL-5 and IL-10. Another key immunological function of IL-4 is to induce immunoglobulin class switching. IL-4 has been shown to induce the production of IgE and enhance IgG4 secretion by B cells, but suppress the production of IgM, IgA, IgG1, IgG2 and IgG3. It has been determined that Stat6 is rapidly tyrosine phosphorylated following stimulation of IL-3 or IL-4, but is not detectably phosphorylated following stimulation with IL-2, IL-12 or erythropoietin. |
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IL-4 Antibody |
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| V8351-100UG | NSJ Bioreagents | 100 ug | EUR 499 |
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Description: IL-4 is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. IL-4 is a potent lymphoid cell growth factor, which stimulates the growth and activation of certain B cells and T cells. IL-4 is important for regulation of T helper subset development. IL-4 is expressed primarily by activated Th2 cells and NK cells, and at lower levels by mast cells, and basophils. IL-4 signals through the IL-4R, and dendritic cell IL-12. |
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IL-4 Antibody |
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| V8351-20UG | NSJ Bioreagents | 20 ug | EUR 219 |
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Description: IL-4 is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. IL-4 is a potent lymphoid cell growth factor, which stimulates the growth and activation of certain B cells and T cells. IL-4 is important for regulation of T helper subset development. IL-4 is expressed primarily by activated Th2 cells and NK cells, and at lower levels by mast cells, and basophils. IL-4 signals through the IL-4R, and dendritic cell IL-12. |
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