Quite a few monoclonal antibodies have been developed efficiently for the therapy of varied ailments. Nonetheless, the event of biotherapeutic antibodies is advanced, costly, and time-consuming, and to facilitate this course of, cautious structural evaluation past the antibody binding web site is required to develop a extra efficacious antibody.
- On this work, we targeted on protein antigens, since they induce the most important antibody modifications, and supply attention-grabbing instances to match and distinction. The constructions of 15 anti-protein antibodies had been analysed to match the antigen-bound/unbound types.
- Surprisingly, three completely different courses of binding-induced modifications had been recognized. In school (B1), the antigen binding fragment distorted considerably, and we discovered modifications within the loop area of the heavy chain’s fixed area; this corresponds properly with anticipated allosteric actions. In school (B2), we discovered modifications in the identical loop area with out the general distortion.
- In school (B3), these modifications didn’t current, and solely native modifications on the complementarity figuring out areas had been discovered. Consequently, structural evaluation of antibodies is essential for therapeutic growth. Cautious analysis of allosteric actions should be undertaken
- to develop higher effector responses, particularly in the course of the transformation of those antibodies from small fragments on the discovery stage to full antibodies on the subsequent growth phases.
genediag
 Anti-IL-17 alpha antibody |
|
STJ93683 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to IL-17Ralpha. |
 IL-17/IL-17A |
|
E21-021 |
EnoGene |
10ug |
EUR 343 |
 IL-6, Interleukin-6, rat |
|
RC252-17 |
Bio Basic |
2ug |
EUR 104.38 |
|
|
 Recombinant Human IL-17 |
|
SJB09-03 |
Amyotop |
25µg/vial |
EUR 256 |
 Antibody) Interleukin 17 (IL-17) Antibody |
|
abx234224-100ug |
Abbexa |
100 ug |
EUR 509 |
|
|
Interleukin 17 (IL-17) Antibody |
|
abx234225-100ug |
Abbexa |
100 ug |
EUR 481 |
|
|
) IL-6, Interleukin-6, murine (mouse) |
|
RC232-17 |
Bio Basic |
2ug |
EUR 104.38 |
|
|
 IL-17 Antibody |
|
24784-100ul |
SAB |
100ul |
EUR 390 |
IL-17 Antibody |
|
24789-100ul |
SAB |
100ul |
EUR 390 |
IL-17 Antibody |
|
4877-002mg |
ProSci |
0.02 mg |
EUR 171.82 |
|
|
|
Description: IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases. |
IL-17 Antibody |
|
4877-01mg |
ProSci |
0.1 mg |
EUR 436.42 |
|
|
|
Description: IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases. |
IL-17 Antibody |
|
4887-002mg |
ProSci |
0.02 mg |
EUR 171.82 |
|
|
|
Description: IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases. |
IL-17 Antibody |
|
4887-01mg |
ProSci |
0.1 mg |
EUR 436.42 |
|
|
|
Description: IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases. |
 IL-17 Peptide |
|
4877P |
ProSci |
0.05 mg |
EUR 164.75 |
|
Description: (NT) IL-17 peptide |
IL-17 Peptide |
|
4887P |
ProSci |
0.05 mg |
EUR 164.75 |
|
Description: (IN) IL-17 peptide |
 Rabbit Polyclonal antibody Anti-CRBN |
|
Anti-CRBN |
ImmunoStep |
50 µg |
EUR 349 |
 IL-17 Interleukin-17 Human Recombinant Protein |
|
PROTQ16552-1 |
BosterBio |
Regular: 25ug |
EUR 317 |
|
Description: Interleukin-17A Human Recombinant produced in E.Coli is a homodimeric, non-glycosylated polypeptide chain containing a total of 264 amino acids (2 chains of 132 aa) and having a molecular mass of 31kDa. ;The IL-17 is purified by proprietary chromatographic techniques. |
ELISA Kit) Human Interleukin 17(IL-17)ELISA Kit |
|
GA-E0081HM-48T |
GenAsia Biotech |
48T |
EUR 289 |
Human Interleukin 17(IL-17)ELISA Kit |
|
GA-E0081HM-96T |
GenAsia Biotech |
96T |
EUR 466 |
 Human Interleukin 17,IL-17 ELISA Kit |
|
201-12-0143 |
SunredBio |
96 tests |
EUR 440 |
|
|
|
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
 CLIA Kit) Human Interleukin 17 (IL-17) CLIA Kit |
|
abx195860-96tests |
Abbexa |
96 tests |
EUR 825 |
|
|
Human Interleukin 17,IL-17 ELISA Kit |
|
CN-03335H1 |
ChemNorm |
96T |
EUR 434 |
Human Interleukin 17,IL-17 ELISA Kit |
|
CN-03335H2 |
ChemNorm |
48T |
EUR 284 |
) IL-6, Interleukin-6, monkey (rhesus macaque) |
|
RC222-17 |
Bio Basic |
2ug |
EUR 104.38 |
|
|
 Protein) Recombinant Human IL-17 (IL-17A) Protein |
|
PROTQ16552-4 |
BosterBio |
25ug |
EUR 317 |
|
Description: The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant human IL-17A is a 31.3 kDa disulfide-linked homodimer of two 137 amino acid polypeptide chains. |
 human IL-17, His tag |
|
E410A10-100 |
EnoGene |
100μg |
EUR 960 |
 Human IL-17 ELISA kit |
|
LF-EK50201 |
Abfrontier |
1×96T |
EUR 648 |
 ELISA Kit) IL-17 (Human) ELISA Kit |
|
E4628-100 |
Biovision |
|
EUR 729 |
 ELISA Kit) 17-Hydroxyprogesterone (17-OHP) ELISA Kit |
|
DLR-17-OHP-Ge-48T |
DL Develop |
48T |
EUR 469 |
|
|
|
Description: A competitive inhibition quantitative ELISA assay kit for detection of 17-Hydroxyprogesterone (17-OHP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
17-Hydroxyprogesterone (17-OHP) ELISA Kit |
|
DLR-17-OHP-Ge-96T |
DL Develop |
96T |
EUR 608 |
|
|
|
Description: A competitive inhibition quantitative ELISA assay kit for detection of 17-Hydroxyprogesterone (17-OHP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
 IL-17 Interleukin-17 Human Recombinant Protein, HEK |
|
PROTQ16552 |
BosterBio |
Regular: 10ug |
EUR 317 |
|
Description: IL-17 Human Recombinant produced in HEK cells is a glycosylated homodimer, having a molecular weight range of 30-35kDa due to glycosylation.;The IL-17 is purified by proprietary chromatographic techniques. |
) ELISA kit for Human IL-17 (Interleukin 17) |
|
E-EL-H0105 |
Elabscience Biotech |
1 plate of 96 wells |
EUR 377 |
|
|
|
Description: A sandwich ELISA kit for quantitative measurement of Human IL-17 (Interleukin 17) in samples from Serum, Plasma, Cell supernatant |
) CLIA kit for Human IL-17 (Interleukin 17) |
|
E-CL-H0104 |
Elabscience Biotech |
1 plate of 96 wells |
EUR 584 |
|
|
|
Description: A sandwich CLIA kit for quantitative measurement of Human IL-17 (Interleukin 17) in samples from Serum, Plasma, Cell supernatant |
 Detection Assay Kit) Human Interleukin 17 (IL-17) Detection Assay Kit |
|
6808 |
Chondrex |
1 kit |
EUR 483.55 |
|
Description: Human Interleukin 17 (IL-17) Detection Assay Kit |
 ELISA Kit) General 17-Hydroxyprogesterone (17-OHP) ELISA Kit |
|
RD-17-OHP-Ge-48Tests |
Cusabio |
48 Tests |
EUR 467 |
General 17-Hydroxyprogesterone (17-OHP) ELISA Kit |
|
RD-17-OHP-Ge-96Tests |
Reddot Biotech |
96 Tests |
EUR 646 |
General 17-Hydroxyprogesterone (17-OHP) ELISA Kit |
|
RDR-17-OHP-Ge-48Tests |
Reddot Biotech |
48 Tests |
EUR 488 |
General 17-Hydroxyprogesterone (17-OHP) ELISA Kit |
|
RDR-17-OHP-Ge-96Tests |
Reddot Biotech |
96 Tests |
EUR 676 |
 Polyclonal IL-17 Antibody |
|
APR06508G |
Leading Biology |
0.1 mg |
EUR 659 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-17 . This antibody is tested and proven to work in the following applications: |
Polyclonal IL-17 Antibody |
|
APR06512G |
Leading Biology |
0.1 mg |
EUR 659 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-17 . This antibody is tested and proven to work in the following applications: |
 IL-17 Recombinant Protein |
|
91-015 |
ProSci |
0.05 mg |
EUR 364.25 |
|
Description: Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation. |
IL-17 Recombinant Protein |
|
91-616 |
ProSci |
0.05 mg |
EUR 490.25 |
|
Description: Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation. |
 Chicken Interleukin 17, IL-17 ELISA Kit |
|
CSB-E04607Ch-24T |
Cusabio |
1 plate of 24 wells |
EUR 165 |
|
|
|
Description: Quantitativecompetitive ELISA kit for measuring Chicken Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Chicken Interleukin 17, IL-17 ELISA Kit |
|
1-CSB-E04607Ch |
Cusabio |
-
EUR 603.00
-
EUR 4247.00
-
EUR 2260.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
|
|
Description: Quantitativecompetitive ELISA kit for measuring Chicken Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
 Mouse Interleukin 17, IL-17 ELISA Kit |
|
CSB-E04608m-24T |
Cusabio |
1 plate of 24 wells |
EUR 165 |
|
|
|
Description: Quantitativesandwich ELISA kit for measuring Mouse Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates, cell culture supernates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Mouse Interleukin 17, IL-17 ELISA Kit |
|
1-CSB-E04608m |
Cusabio |
-
EUR 603.00
-
EUR 4247.00
-
EUR 2260.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
|
|
Description: Quantitativesandwich ELISA kit for measuring Mouse Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates, cell culture supernates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
ELISA Kit) Canine Interleukin 17(IL-17)ELISA Kit |
|
CSB-E17935c-24T |
Cusabio |
1 plate of 24 wells |
EUR 165 |
|
|
|
Description: Quantitativesandwich ELISA kit for measuring Canine Interleukin 17 (IL-17) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Canine Interleukin 17(IL-17)ELISA Kit |
|
1-CSB-E17935c |
Cusabio |
-
EUR 900.00
-
EUR 5476.00
-
EUR 2900.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
|
|
Description: Quantitativesandwich ELISA kit for measuring Canine Interleukin 17(IL-17) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
 Rat Interleukin 17, IL-17 ELISA KIT |
|
CSB-E07451r-24T |
Cusabio |
1 plate of 24 wells |
EUR 165 |
|
|
|
Description: Quantitativesandwich ELISA kit for measuring Rat Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Rat Interleukin 17, IL-17 ELISA KIT |
|
1-CSB-E07451r |
Cusabio |
-
EUR 603.00
-
EUR 4247.00
-
EUR 2260.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
|
|
Description: Quantitativesandwich ELISA kit for measuring Rat Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
 Pig interleukin 17, IL-17 ELISA Kit |
|
CSB-E08057p-24T |
Cusabio |
1 plate of 24 wells |
EUR 165 |
|
|
|
Description: Quantitativesandwich ELISA kit for measuring Pig interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Pig interleukin 17, IL-17 ELISA Kit |
|
1-CSB-E08057p |
Cusabio |
-
EUR 603.00
-
EUR 4247.00
-
EUR 2260.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
|
|
Description: Quantitativesandwich ELISA kit for measuring Pig interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
 Rabbit Interleukin 17, IL-17 ELISA Kit |
|
CSB-E08058Rb-24T |
Cusabio |
1 plate of 24 wells |
EUR 165 |
|
|
|
Description: Quantitativesandwich ELISA kit for measuring Rabbit Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Rabbit Interleukin 17, IL-17 ELISA Kit |
|
1-CSB-E08058Rb |
Cusabio |
-
EUR 603.00
-
EUR 4247.00
-
EUR 2260.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
|
|
Description: Quantitativesandwich ELISA kit for measuring Rabbit Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
 ELISA Kit) Bovine Interleukin 17(IL-17) ELISA Kit |
|
CSB-E14207B-24T |
Cusabio |
1 plate of 24 wells |
EUR 165 |
|
|
|
Description: Quantitativesandwich ELISA kit for measuring Bovine Interleukin 17 (IL-17) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Bovine Interleukin 17(IL-17) ELISA Kit |
|
1-CSB-E14207B |
Cusabio |
-
EUR 900.00
-
EUR 5476.00
-
EUR 2900.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
|
|
Description: Quantitativesandwich ELISA kit for measuring Bovine Interleukin 17(IL-17) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
 IL-17 Interleukin-17 Rat Recombinant Protein |
|
PROTQ61453 |
BosterBio |
Regular: 25ug |
EUR 317 |
|
Description: Interleukin-17A Rat Recombinant produced in E.Coli is a homodimeric, non-glycosylated polypeptide chain having a molecular mass of 30 kDa. ;The IL-17A Rat is purified by proprietary chromatographic techniques. |
 IL-17 Interleukin-17 Mouse Recombinant Protein |
|
PROTQ62386 |
BosterBio |
Regular: 25ug |
EUR 317 |
|
Description: Interleukin-17 Murine Recombinant produced in E.Coli is a homodimeric, non-glycosylated polypeptide chain containing a total of 268 (2x134 a.a.) amino acids and having a molecular mass of 30 kDa. ; The IL-17 is purified by proprietary chromatographic techniques. |
 Rabbit Interleukin 17,IL-17 ELISA Kit |
|
GA-E0112RB-48T |
GenAsia Biotech |
48T |
EUR 326 |
Rabbit Interleukin 17,IL-17 ELISA Kit |
|
GA-E0112RB-96T |
GenAsia Biotech |
96T |
EUR 524 |
ELISA Kit) Rat Interleukin 17(IL-17)ELISA Kit |
|
GA-E0124RT-48T |
GenAsia Biotech |
48T |
EUR 354 |
Rat Interleukin 17(IL-17)ELISA Kit |
|
GA-E0124RT-96T |
GenAsia Biotech |
96T |
EUR 571 |
ELISA Kit) Mouse Interleukin 17(IL-17)ELISA Kit |
|
GA-E0063MS-48T |
GenAsia Biotech |
48T |
EUR 336 |
Mouse Interleukin 17(IL-17)ELISA Kit |
|
GA-E0063MS-96T |
GenAsia Biotech |
96T |
EUR 534 |
 CLIA Kit) Mouse Interleukin 17 (IL-17) CLIA Kit |
|
abx195861-96tests |
Abbexa |
96 tests |
EUR 825 |
|
|
 CLIA Kit) Rat Interleukin 17 (IL-17) CLIA Kit |
|
abx195862-96tests |
Abbexa |
96 tests |
EUR 825 |
|
|
 ELISA Kit) Rabbit IL-17(Interleukin 17) ELISA Kit |
|
ERB0160 |
FN Test |
96T |
EUR 567.6 |
|
|
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rabbit;Sensitivity: 9.375pg/ml |
Drug Tolerant Anti-drug Antibody Assay for Infliximab Remedy in Scientific Observe Identifies Constructive Instances Earlier
A subgroup of sufferers handled with infliximab lose response to the therapy and one purpose for that is the event of anti-drug antibodies (ADA). If used optimally, measuring drug and ADA degree might result in a extra personalised and environment friendly therapy regime, and allow identification of ADA-positive sufferers earlier than the underlying illness flares or allergic reactions happen.
With the usage of a drug-tolerant ADA assay which might detect ADA no matter drug ranges within the pattern, we decided the affect of ADA on therapy failure to infliximab. The goals of this research had been to estimate the real-life optimum serum infliximab (sIFX) degree and set a medical threshold worth for a drug-tolerant ADA assay. Trough ranges of sIFX had been measured with ELISA. Free ADA was measured with two drug-sensitive strategies (ELISA and a bioassay) and one drug-tolerant technique (PandA).
Two real-life cohorts handled with infliximab had been included; a cross-sectional cohort together with sufferers with inflammatory rheumatic ailments (n = 270) and a potential cohort of rheumatoid arthritis (RA) sufferers (n = 73) adopted for 1 yr. Regular vary of sIFX was estimated from the potential cohort and an arbitrary optimum drug degree was set to be between 1 and 6 μg/mL.
Utilizing this vary, optimum sIFX was present in solely 60% (163/270) of the sufferers within the cross-sectional cohort. These sufferers had considerably higher therapy response than these with a drug degree below 1 μg/mL, who had an ADA frequency of 34% (19/56) utilizing the drug-tolerant technique.
Within the potential cohort, the drug-tolerant assay might determine 34% (53/155 samples) as ADA optimistic in samples with sIFX degree >0.2 μg/mL. ADA had been seldom detected in sufferers with >1 μg/mL sIFX, with three attention-grabbing exceptions. A clinically related ADA threshold was decided to be >three RECL as measured with the drug-tolerant assay.
In a real-life setting, there was a substantial variety of sufferers with suboptimal drug ranges and a proportion of those had ADA. Each too low and too excessive drug ranges correlated with worse illness, however for various causes. Including a drug-tolerant assay enabled detection of ADA earlier and no matter drug degree at time of sampling.
 Alpha V Beta 5 Integrin, Peptide Aptamer, FITC labelled |
|
AP-301-F |
Alpha Diagnostics |
1 mg |
Ask for price |
 Protein) Human Integrin Alpha 5 (ITGa5) Protein |
|
20-abx067272 |
Abbexa |
-
EUR 662.00
-
EUR 272.00
-
EUR 2040.00
-
EUR 787.00
-
EUR 481.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
|
 anti-Integrin beta 5 |
|
YF-PA12792 |
Abfrontier |
100 ug |
EUR 403 |
|
Description: Rabbit polyclonal to Integrin beta 5 |
anti-Integrin beta 5 |
|
YF-PA24023 |
Abfrontier |
50 ul |
EUR 334 |
|
Description: Mouse polyclonal to Integrin beta 5 |
) Recombinant Integrin Alpha 5 (ITGa5) |
|
4-RPB287Bo01 |
Cloud-Clone |
-
EUR 556.96
-
EUR 252.00
-
EUR 1813.60
-
EUR 671.20
-
EUR 1242.40
-
EUR 436.00
-
EUR 4384.00
|
- 100 ug
- 10ug
- 1 mg
- 200 ug
- 500 ug
- 50ug
- 5 mg
|
|
|
|
Description: Recombinant Bovine Integrin Alpha 5 expressed in: E.coli |
Recombinant Integrin Alpha 5 (ITGa5) |
|
4-RPB287Hu01 |
Cloud-Clone |
-
EUR 476.32
-
EUR 230.00
-
EUR 1511.20
-
EUR 570.40
-
EUR 1040.80
-
EUR 382.00
-
EUR 3628.00
|
- 100 ug
- 10ug
- 1 mg
- 200 ug
- 500 ug
- 50ug
- 5 mg
|
|
|
|
Description: Recombinant Human Integrin Alpha 5 expressed in: E.coli |
Recombinant Integrin Alpha 5 (ITGa5) |
|
4-RPB287Mu01 |
Cloud-Clone |
-
EUR 476.32
-
EUR 230.00
-
EUR 1511.20
-
EUR 570.40
-
EUR 1040.80
-
EUR 382.00
-
EUR 3628.00
|
- 100 ug
- 10ug
- 1 mg
- 200 ug
- 500 ug
- 50ug
- 5 mg
|
|
|
|
Description: Recombinant Mouse Integrin Alpha 5 expressed in: E.coli |
 Antibody) Integrin Alpha 5 (ITGa5) Antibody |
|
20-abx129339 |
Abbexa |
-
EUR 425.00
-
EUR 133.00
-
EUR 1177.00
-
EUR 578.00
-
EUR 328.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
|
 Antibody) Integrin Alpha 5 (ITGA5) Antibody |
|
20-abx113185 |
Abbexa |
|
|
|
|
Integrin Alpha 5 (ITGA5) Antibody |
|
20-abx323564 |
Abbexa |
|
|
|
|
Integrin Alpha 5 (ITGA5) Antibody |
|
20-abx338742 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
|
Integrin Alpha 5 (ITGa5) Antibody |
|
20-abx101634 |
Abbexa |
-
EUR 411.00
-
EUR 133.00
-
EUR 1149.00
-
EUR 565.00
-
EUR 314.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
|
Integrin Alpha 5 (ITGa5) Antibody |
|
20-abx101635 |
Abbexa |
-
EUR 467.00
-
EUR 133.00
-
EUR 1344.00
-
EUR 634.00
-
EUR 356.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
|
Integrin Alpha 5 (ITGA5) Antibody |
|
20-abx000873 |
Abbexa |
|
|
|
|
Integrin Alpha 5 (ITGA5) Antibody |
|
20-abx006811 |
Abbexa |
-
EUR 411.00
-
EUR 592.00
-
EUR 182.00
-
EUR 314.00
|
- 100 ul
- 200 ul
- 20 ul
- 50 ul
|
|
|
Integrin Alpha 5 (ITGA5) Antibody |
|
abx011678-100ul |
Abbexa |
100 ul |
EUR 411 |
|
|
Integrin Alpha 5 (ITGA5) Antibody |
|
abx026655-400ul |
Abbexa |
400 ul |
EUR 523 |
|
|
Integrin Alpha 5 (ITGA5) Antibody |
|
abx026655-80l |
Abbexa |
80 µl |
EUR 286 |
|
|
 Integrin alpha 5 Rabbit mAb |
|
A19069-100ul |
Abclonal |
100 ul |
EUR 410 |
Integrin alpha 5 Rabbit mAb |
|
A19069-200ul |
Abclonal |
200 ul |
EUR 571 |
Integrin alpha 5 Rabbit mAb |
|
A19069-20ul |
Abclonal |
20 ul |
EUR 221 |
Integrin alpha 5 Rabbit mAb |
|
A19069-50ul |
Abclonal |
50 ul |
EUR 287 |
Integrin Alpha 5 (ITGa5) Antibody |
|
20-abx179024 |
Abbexa |
|
|
|
|
Integrin Alpha 5 (ITGa5) Antibody |
|
20-abx172956 |
Abbexa |
|
|
|
|
 Antibody) Integrin alpha 5 (CD49e) Antibody |
|
abx216264-100ug |
Abbexa |
100 ug |
EUR 439 |
|
|
Integrin Alpha 5 (ITGA5) Antibody |
|
20-abx327245 |
Abbexa |
|
|
|
|
Integrin Alpha 5 (ITGA5) Antibody |
|
20-abx325454 |
Abbexa |
|
|
|
|
 Integrin alpha 5 Conjugated Antibody |
|
C49269 |
SAB |
100ul |
EUR 397 |
 Antibody) Integrin alpha 5 (CD49e) Antibody |
|
AF5200 |
Affbiotech |
200ul |
EUR 304 |
|
Description: Integrin α5 (CD49e) Antibody detects endogenous levels of total Integrin α5 (CD49e). |
 Integrin alpha-5 Recombinant Protein |
|
91-433 |
ProSci |
0.05 mg |
EUR 542.75 |
|
Description: Integrin alpha-5 belongs to the Integrin alpha chain family and contains 7 FG-GAP repeats. Integrin alpha-5 joins with Integrin- beta 1 to form a fibronectin and laminin receptor which recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. It is expressed on fibroblasts, endothelial cells, peripheral T cells and platelets. Integrin alpha-5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains. In addition to adhesion, ITGA5 participates in cell-surface mediated signalling. |
,antiserum #1) Rabbit Anti-Human Alpha Defensin 5 (NP-5),antiserum #1 |
|
HDEFA51-S |
Alpha Diagnostics |
100 ul |
EUR 457 |
 Anti-Integrin alpha antibody |
|
STJ96613 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to Integrin alpha4. |
Anti-Integrin alpha antibody |
|
STJ96825 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to Integrin alphaD. |
Anti-Integrin alpha antibody |
|
STJ97273 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to Integrin alphaL. |
Anti-Integrin alpha antibody |
|
STJ97283 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to Integrin alpha2. |
Anti-Integrin alpha antibody |
|
STJ97284 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Integrin alpha5 is a protein encoded by the ITGA5 gene which is approximately 114,5 kDa. Integrin alpha5 is localised to the cell membrane and is involved in the MAPK-Erk pathway, apoptotic pathways, integrin pathway, focal adhesion and blood-brain barrier and immune cell transmigration. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signalling. Integrin alpha5 is expressed in the liver, lung, nervous system, bone marrow and blood. Mutations in the ITGA5 gene may result in colon carcinoma and congenital epulis STJ97284 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Integrin alpha5 protein. |
Anti-Integrin alpha antibody |
|
STJ97285 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to Integrin alpha6. |
Anti-Integrin alpha antibody |
|
STJ97657 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to Integrin alpha3. |
Anti-Integrin alpha antibody |
|
STJ98181 |
St John's Laboratory |
100 µl |
EUR 234 |
|
Description: Mouse monoclonal to Integrin alpha5. |
Anti-Integrin alpha antibody |
|
STJ98510 |
St John's Laboratory |
100 µl |
EUR 234 |
|
Description: Mouse monoclonal to Integrin alpha5. |
Anti-Integrin alpha antibody |
|
STJ98511 |
St John's Laboratory |
100 µl |
EUR 234 |
|
Description: Mouse monoclonal to Integrin alpha6. |
Anti-Integrin alpha antibody |
|
STJ98709 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to Integrin alpha1. |
Anti-Integrin alpha antibody |
|
STJ98737 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to Integrin alphaX. |
Anti-Integrin alpha antibody |
|
STJ93727 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to Integrin alpha3. |
Anti-Integrin alpha antibody |
|
STJ93728 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to Integrin alpha4. |
Anti-Integrin alpha antibody |
|
STJ93729 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to Integrin alphaE. |
Anti-Integrin alpha antibody |
|
STJ93730 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to Integrin alphaV. |
Anti-Integrin alpha antibody |
|
STJ98984 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to Integrin alphaE. |
 anti-Integrin alpha 6 |
|
YF-PA12761 |
Abfrontier |
50 ul |
EUR 363 |
|
Description: Mouse polyclonal to Integrin alpha 6 |
anti-Integrin alpha 6 |
|
YF-PA12762 |
Abfrontier |
100 ug |
EUR 403 |
|
Description: Rabbit polyclonal to Integrin alpha 6 |
 anti-Integrin alpha 1 |
|
YF-PA12784 |
Abfrontier |
50 ug |
EUR 363 |
|
Description: Mouse polyclonal to Integrin alpha 1 |
 anti-Integrin alpha 4 |
|
YF-PA12785 |
Abfrontier |
100 ug |
EUR 403 |
|
Description: Rabbit polyclonal to Integrin alpha 4 |
 anti-Integrin alpha V |
|
YF-PA12786 |
Abfrontier |
50 ul |
EUR 363 |
|
Description: Mouse polyclonal to Integrin alpha V |
anti-Integrin alpha V |
|
YF-PA12787 |
Abfrontier |
50 ug |
EUR 363 |
|
Description: Mouse polyclonal to Integrin alpha V |
anti-Integrin alpha V |
|
YF-PA12788 |
Abfrontier |
100 ug |
EUR 403 |
|
Description: Rabbit polyclonal to Integrin alpha V |
anti-Integrin alpha 6 |
|
YF-PA24004 |
Abfrontier |
50 ul |
EUR 334 |
|
Description: Mouse polyclonal to Integrin alpha 6 |
anti-Integrin alpha 1 |
|
YF-PA24011 |
Abfrontier |
50 ul |
EUR 334 |
|
Description: Mouse polyclonal to Integrin alpha 1 |
anti-Integrin alpha 4 |
|
YF-PA24013 |
Abfrontier |
50 ul |
EUR 334 |
|
Description: Mouse polyclonal to Integrin alpha 4 |
 anti-Integrin alpha 9 |
|
YF-PA24015 |
Abfrontier |
50 ul |
EUR 334 |
|
Description: Mouse polyclonal to Integrin alpha 9 |
 anti-Integrin alpha E |
|
YF-PA24017 |
Abfrontier |
50 ul |
EUR 334 |
|
Description: Mouse polyclonal to Integrin alpha E |
 Mouse Anti Human Integrin Alpha V Beta 5 Monoclonal Antibody |
|
CABT-49626MH |
Creative Diagnostics |
0.1 mg |
EUR 1375 |
, Human IgG4 Antibody) Anti-alpha 5 beta 1 Integrin (Volociximab), Human IgG4 Antibody |
|
A1092-200 |
Biovision |
|
EUR 729 |
 ELISA Kit) Human Integrin Alpha 5 (ITGa5) ELISA Kit |
|
SEB287Hu-10x96wellstestplate |
Cloud-Clone |
10x96-wells test plate |
EUR 4502.43 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Integrin Alpha 5 (ITGa5) in Tissue homogenates, cell lysates and other biological fluids. |
Human Integrin Alpha 5 (ITGa5) ELISA Kit |
|
SEB287Hu-1x48wellstestplate |
Cloud-Clone |
1x48-wells test plate |
EUR 458.44 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Integrin Alpha 5 (ITGa5) in Tissue homogenates, cell lysates and other biological fluids. |
Human Integrin Alpha 5 (ITGa5) ELISA Kit |
|
SEB287Hu-1x96wellstestplate |
Cloud-Clone |
1x96-wells test plate |
EUR 612.05 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Integrin Alpha 5 (ITGa5) in Tissue homogenates, cell lysates and other biological fluids. |
Human Integrin Alpha 5 (ITGa5) ELISA Kit |
|
SEB287Hu-5x96wellstestplate |
Cloud-Clone |
5x96-wells test plate |
EUR 2454.23 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Integrin Alpha 5 (ITGa5) in Tissue homogenates, cell lysates and other biological fluids. |
Human Integrin Alpha 5 (ITGa5) ELISA Kit |
|
4-SEB287Hu |
Cloud-Clone |
-
EUR 4553.00
-
EUR 2405.00
-
EUR 613.00
|
- 10 plates of 96 wells
- 5 plates of 96 wells
- 1 plate of 96 wells
|
|
|
|
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Integrin Alpha 5 (ITGa5) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. |
 Elisa kit) Human Integrin alpha-5(ITGA5) Elisa kit |
|
CSB-E17350h-24T |
Cusabio |
1 plate of 24 wells |
EUR 165 |
|
|
|
Description: Quantitativesandwich ELISA kit for measuring Human Integrin alpha-5 (ITGA5) in samples from serum, plasma, cell culture supernates, urine, cerebrospinalfluid (CSF). A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Human Integrin alpha-5(ITGA5) Elisa kit |
|
1-CSB-E17350h |
Cusabio |
-
EUR 900.00
-
EUR 5476.00
-
EUR 2900.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
|
|
Description: Quantitativesandwich ELISA kit for measuring Human Integrin alpha-5(ITGA5) in samples from serum, plasma, cell culture supernates, urine, cerebrospinalfluid(CSF). Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
 Polyclonal Antibody (Human)) Integrin Alpha 5 (ITGa5) Polyclonal Antibody (Human) |
|
4-PAB287Hu01 |
Cloud-Clone |
-
EUR 239.00
-
EUR 2391.00
-
EUR 598.00
-
EUR 299.00
-
EUR 211.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Human Integrin Alpha 5 (ITGa5) |
Human Integrin Alpha 5 (ITGa5) ELISA Kit |
|
RD-ITGa5-Hu-48Tests |
Reddot Biotech |
48 Tests |
EUR 500 |
Human Integrin Alpha 5 (ITGa5) ELISA Kit |
|
RD-ITGa5-Hu-96Tests |
Reddot Biotech |
96 Tests |
EUR 692 |
 Human ITGA5/ Integrin alpha-5 ELISA Kit |
|
E1342Hu |
Sunlong |
1 Kit |
EUR 605 |
