August 24, 2020
Research for Disulfide-Linked, Self-Immolating Subsequent-Technology Antibody Drug
Conjugation Site Influences Antibody-Conjugated Drug PK Assays: Case Studies for Disulfide-Linked, Self-Immolating Next-Generation Antibody Drug Conjugates
Immunoaffinity (IA) LC-MS/MS pharmacokinetic (PK) assays are widely used in the field for antibody drug conjugates (ADCs) containing peptide linkers that are enzymatically cleavable, such as MC-ValCit-PAB. Conjugate PK assay strategies for these ADCs involve cleavage with cathepsin B or papain to release and measure the antibody-conjugated drug (acDrug) concentration.
However, robust acDrug PK methods for disulfide-linked self-immolating ADCs are lacking as they are a different conjugation modality. We developed acDrug PK assays for next-generation disulfide-linked ADCs involving immunoaffinity capture, chemical cleavage, and LC-MS/MS. Disulfide-linked ADCs captured from plasma were chemically reduced at basic pH to release the linker-drug, followed by self-immolation to liberate the active drug, and quantified by MRM LC-MS/MS.
Herein, we detail the development and optimization of this chemical cleavage acDrug PK assay, resulting in robust accuracy and precision (<u>+</u>20%). The conjugation site of the linker-drug on the antibody was found to affect the kinetics of drug release.
Multiple biophysical and chemical characteristics, such as tertiary structure, fractional solvent accessibility, pKa of the conjugation site, surrounding residue’s pI, and electrostatic charge, may directly impact the drug release kinetics. Similar site-specific stability has been previously reported for ADCs in vivo.
The assay development and qualification data for this original assay format are presented along with its application to multiple in vitro and in vivo studies across species.
Gestational Dysfunction-Driven Diets and Probiotic Supplementation Correlate with the Profile of Allergen-Specific Antibodies in the Serum of Allergy Sufferers
Background: Maternal diet has significant effects on development of childhood atopic disease and hypersensitivity development. However, the gestational dysfunctions demanding special diets are becoming a widespread phenomenon, their immunological implications can be manifested in the profile of antibodies in the offspring’s serum.
Methods: 153 allergic and 150 healthy individuals were diagnosed for allergy using specific antibody and cytokine immunoassay tests. The medical history of subjects along with mothers’ course of pregnancy was completed by allergologist’s anamnesis. A self-organizing neural network and multivariate analyses to complex data and pick basic interactions were used.
Results: Two significant explanatory modules were determined. The first was formed by gestational diabetic and cholestatic diet, infant formula feeding type, probiotic supplementation and its BMI index, moderate IgE, increased IgG levels of antibodies and single or poly-food allergy type (7 clusters).
The second was formed by gestational vegan/vegetarian and elimination diet, maternal probiotic supplementation, sex, high IgE total antibodies and food and mixed poly-allergy to aero- and food-origin allergens (19 clusters).
Conclusions: Significant associations were observed between special gestational diet intake underlying foetal programming and the mechanisms of childhood allergy. The novelty is the positive association between diabetic and cholestatic diet intake and IgE/IgG-mediated food hypersensitivity.
Keywords: allergic patterns; allergy prevalence; artificial self-organizing neural network; foetal programming; gestational dysfunction-driven diets; probiotics supplementation; specific IgE-antibodies profile.
genediag
 Anti-human TNF-alpha antibody |
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| STJ15100115 | St John's Laboratory | 250 µg | EUR 367 |
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Description: This monoclonal antibody enables sensitive and specific detection of human TNF-α in Flow cytometry and Western blot. |
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Anti-human TNF-alpha antibody |
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| STJ15100116 | St John's Laboratory | 250 µg | EUR 336 |
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Description: We recommend MT25C5 as capture antibody in ELISA and ELISpot in combination with biotinylated detection antibody MT20D9. |
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Anti-human TNF-alpha antibody |
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| STJ15100117 | St John's Laboratory | 250 µg | EUR 367 |
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Description: This monoclonal antibody enables sensitive and specific detection of human TNF-α in immunoassays such as ELISA and ELISpot. |
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 Anti-TNF alpha Purified |
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| 11-687-C025 | ExBio | 0.025 mg | EUR 99 |
Anti-TNF alpha Purified |
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| 11-687-C100 | ExBio | 0.1 mg | EUR 158 |
Anti-TNF alpha Purified |
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| 11-688-C025 | ExBio | 0.025 mg | EUR 99 |
Anti-TNF alpha Purified |
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| 11-688-C100 | ExBio | 0.1 mg | EUR 158 |
 Anti-TNF alpha APC |
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| 1A-688-T025 | ExBio | 25 tests | EUR 140 |
Anti-TNF alpha APC |
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| 1A-688-T100 | ExBio | 100 tests | EUR 240 |
 Anti-TNF alpha FITC |
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| 1F-688-T025 | ExBio | 25 tests | EUR 122 |
Anti-TNF alpha FITC |
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| 1F-688-T100 | ExBio | 100 tests | EUR 204 |
 Anti-TNF alpha PE |
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| 1P-688-T025 | ExBio | 25 tests | EUR 140 |
Anti-TNF alpha PE |
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| 1P-688-T100 | ExBio | 100 tests | EUR 240 |
 Anti-TNF alpha Antibody |
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| A00002-2 | BosterBio | 100ug/vial | EUR 294 |
Anti-TNF alpha Antibody |
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| A00002-3 | BosterBio | 100ug/vial | EUR 294 |
 anti- TNF alpha antibody |
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| FNab08815 | FN Test | 100µg | EUR 585 |
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Description: Antibody raised against TNF alpha |
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 anti- TNF-alpha antibody |
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| FNab08821 | FN Test | 100µg | EUR 585 |
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Description: Antibody raised against TNF-alpha |
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anti- TNF alpha antibody |
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| FNab09822 | FN Test | 100µg | EUR 548.75 |
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Description: Antibody raised against TNF alpha |
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Anti-TNF alpha Antibody |
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| PA1079 | BosterBio | 100ug/vial | EUR 334 |
) anti-TNF-alpha (2A9B9) |
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| LF-MA30138 | Abfrontier | 100 ul | EUR 486 |
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Description: Mouse Monoclonal to TNF-alpha |
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anti- TNF alpha antibody |
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| LSMab09822 | Lifescience Market | 100 ug | EUR 386 |
 Anti-TNF-alpha antibody |
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| PAab08821 | Lifescience Market | 100 ug | EUR 412 |
Anti-TNF alpha Antibody |
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| PB9010 | BosterBio | 100ug/vial | EUR 294 |
Anti-TNF alpha Antibody |
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| PB9246 | BosterBio | 100ug/vial | EUR 294 |
 Anti-TNF alpha antibody |
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| STJ140123 | St John's Laboratory | 150 µg | EUR 408 |
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Description: Goat polyclonal antibody to TNF alpha. TNF-alpha is produced by a variety of immune cells including NK cells, B cells, T cells and macrophages. It is multifunctional proinflammatory cytokine that belongs to the tumour necrosis factor (TNF) superfamily. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is involved in the regulation of several processes including lipid metabolism cell differentiation and proliferation, coagulation and apoptosis. It has been implicated in a variety of diseases, including cancer and autoimmune diseases. |
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 Anti-TNF-Alpha antibody |
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| STJ16100927 | St John's Laboratory | 100 µg | EUR 451 |
Anti-TNF-Alpha antibody |
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| STJ16100932 | St John's Laboratory | 100 µg | EUR 648 |
Anti-TNF-Alpha antibody |
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| STJ16100933 | St John's Laboratory | 50 µg | EUR 531 |
Anti-TNF-Alpha antibody |
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| STJ16100934 | St John's Laboratory | 100 µg | EUR 648 |
Anti-TNF-Alpha antibody |
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| STJ16100935 | St John's Laboratory | 50 µg | EUR 531 |
Anti-TNF-alpha antibody |
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| STJ96054 | St John's Laboratory | 200 µl | EUR 197 |
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Description: TNF-alpha is a protein encoded by the TNF gene which is approximately 25,6 kDa. TNF-alpha is localised to the cell membrane. It is involved in PEDF induced signalling, TNFR1 pathway, allograft rejection and apoptosis modulation and signalling. It is a cytokine that is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, lipid metabolism, and coagulation. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF-alpha is expressed in the blood, lung, spleen, liver and heart. Mutations in the TNF gene may result in psoriatic arthritis. STJ96054 was affinity purified. This polyclonal antibody binds to endogenous TNF-alpha. |
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Anti-TNF-alpha antibody |
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| STJ96516 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Rabbit polyclonal to TNF-alpha. |
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Anti-TNF alpha antibody |
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| STJ97488 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Rabbit polyclonal to TNF alpha. |
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Anti-TNF alpha antibody |
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| STJ97489 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Rabbit polyclonal to TNF alpha. |
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Anti-TNF alpha antibody |
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| STJ97493 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Mouse monoclonal to TNF alpha. |
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Anti-TNF alpha antibody |
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| STJ97494 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Mouse monoclonal to TNF alpha. |
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 IgG #1 aff. Pure) Monoclonal Anti-Human Tumor Necrosis Factor-Alpha (TNF-alpha) IgG #1 aff. Pure |
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| TNFA11-M | Alpha Diagnostics | 100 ug | EUR 482 |
 IgG #2, aff. Pure) Monoclonal Anti-Human Tumor Necrosis Factor-Alpha (TNF-alpha) IgG #2, aff. Pure |
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| TNFA12-M | Alpha Diagnostics | 100 ug | EUR 482 |
 antiserum) Rabbit Anti-Rat TNF-alpha Converting Enzyme (TACE) antiserum |
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| TACE11-S | Alpha Diagnostics | 100 ul | EUR 457 |
 IgG #2, aff. Pure (neutralzing)) Goat Anti-Human Tumor Necrosis Factor-Alpha (TNF-alpha) IgG #2, aff. Pure (neutralzing) |
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| TNFA13-A | Alpha Diagnostics | 100 ul | EUR 482 |
 Anti-human/monkey TNF-alpha antibody |
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| STJ15100118 | St John's Laboratory | 250 µg | EUR 336 |
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Description: This monoclonal antibody enables sensitive and specific detection of monkey TNF-α in immunoassays such as ELISA and ELISpot. |
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Anti-human/monkey TNF-alpha antibody |
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| STJ15100119 | St John's Laboratory | 250 µg | EUR 367 |
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Description: This monoclonal antibody enables sensitive and specific detection of TNF-α in immunoassays such as ELISA and ELISpot, Flow cytometry, and Western blot. |
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 Anti-mouse TNF alpha Antibody |
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| RP1000 | BosterBio | 100ug/vial | EUR 334 |
 Anti-mouse TNF-alpha antibody |
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| STJ15100113 | St John's Laboratory | 250 µg | EUR 336 |
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Description: These monoclonal antibodies enable sensitive and specific detection of mouse TNF-α in immunoassays such as ELISA and ELISpot. |
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Anti-mouse TNF-alpha antibody |
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| STJ15100114 | St John's Laboratory | 250 µg | EUR 367 |
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Description: This monoclonal antibody enables sensitive and specific detection of mouse TNF-α in immunoassays such as ELISA and ELISpot. |
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 Anti-Mouse TNF-alpha antibody |
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| STJ16100926 | St John's Laboratory | 100 µg | EUR 701 |
Anti-Mouse TNF-alpha antibody |
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| STJ16101171 | St John's Laboratory | 1 mL | EUR 801 |
) Anti-TNF alpha (M1-C4) |
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| YF-MA10949 | Abfrontier | 100 ug | EUR 363 |
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Description: Mouse monoclonal to TNF alpha |
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) Anti-TNF alpha (M2-E3) |
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| YF-MA15915 | Abfrontier | 100 ug | EUR 363 |
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Description: Mouse monoclonal to TNF alpha |
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 Human TNF-alpha ELISA Kit, 96 tests, Quantitative |
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| 100-215-TNH | Alpha Diagnostics | 1 kit | EUR 482 |
 TNF alpha |
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| GT15064 | Neuromics | 100 ug | EUR 526 |
TNF alpha |
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| GT15113 | Neuromics | 100 ug | EUR 526 |
 TNF-alpha |
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| PR27146 | Neuromics | 50 ug | EUR 318 |
, IgG aff. Pure) Rabbit Anti-Rat TNF-alpha Converting Enzyme (TACE), IgG aff. Pure |
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| TACE11-A | Alpha Diagnostics | 100 ug | EUR 482 |
, Human IgG4 Antibody) Anti-TNF alpha (Humicade), Human IgG4 Antibody |
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| A1093-200 | Biovision | EUR 729 | |
, Human IgG1 Antibody) Anti-TNF alpha (Infliximab), Human IgG1 Antibody |
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| A1097-200 | Biovision | EUR 778 | |
 Human anti TNF Alpha autoantibody ELISA kit |
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| E01A2132-192T | B-Gene | 192 tests | EUR 1270 |
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Description: A sandwich ELISA for quantitative measurement of Human anti TNF Alpha autoantibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human anti TNF Alpha autoantibody ELISA kit |
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| E01A2132-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
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Description: A sandwich ELISA for quantitative measurement of Human anti TNF Alpha autoantibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human anti TNF Alpha autoantibody ELISA kit |
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| E01A2132-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
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Description: A sandwich ELISA for quantitative measurement of Human anti TNF Alpha autoantibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 purified human Tumor Necrosis Factor-Alpha (TNF-alpha), biologically active) Recombinant (E.Coli) purified human Tumor Necrosis Factor-Alpha (TNF-alpha), biologically active |
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| TNFA15-R-10 | Alpha Diagnostics | 10 ug | EUR 225 |
 Anti-TNF-alpha Antibody Clone TNF/1500R, Unconjugated-20ug |
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| 7124-RBM13-P0 | EnQuireBio | 20ug | EUR 233 |
 Anti-TNF-alpha Antibody Clone TNF/1500R, Unconjugated-100ug |
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| 7124-RBM13-P1 | EnQuireBio | 100ug | EUR 428 |
 Rabbit Polyclonal antibody Anti-CRBN |
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| Anti-CRBN | ImmunoStep | 50 µg | EUR 349 |
 Rapid Test cards, 10/pk) TruStrip RDT Humira/Adalimumab (anti-TNF-alpha) Rapid Test cards, 10/pk |
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| 200-320-RDT | Alpha Diagnostics | 1 pk | EUR 293 |
 Human TNF-alpha antibody |
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| 32809-05111 | AssayPro | 150 ug | EUR 261 |
 TNF-alpha, human recombinant |
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| 1050-10 | Biovision | EUR 153 | |
TNF-alpha, human recombinant |
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| 1050-1000 | Biovision | EUR 1751 | |
TNF-alpha, human recombinant |
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| 1050-50 | Biovision | EUR 283 | |
 Human TNF-alpha Antibody |
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| 13101-05011 | AssayPro | 150 ug | EUR 217 |
 Human TNF alpha Protein |
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| abx060828-005mg | Abbexa | 0.05 mg | EUR 551 |
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 TNF-alpha/TNFSF2, Human |
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| HY-P7058 | MedChemExpress | 100ug | EUR 441 |
 Anti-TNF alpha Purified Azide Free |
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| 10-687-C100 | ExBio | 0.1 mg | EUR 158 |
) Anti-TNF alpha (1C3-A1-F4) |
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| YF-MA15914 | Abfrontier | 100 ug | EUR 363 |
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Description: Mouse monoclonal to TNF alpha |
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 TNF-alpha Antibody |
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| 3052R-100 | Biovision | EUR 316 | |
TNF-alpha Antibody |
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| 3052R-30T | Biovision | EUR 146 | |
TNF-alpha Antibody |
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| 3053R-100 | Biovision | EUR 316 | |
TNF-alpha Antibody |
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| 3053R-30T | Biovision | EUR 146 | |
TNF-alpha Antibody |
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| 3054-100 | Biovision | EUR 316 | |
TNF-alpha Antibody |
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| 3054-30T | Biovision | EUR 146 | |
 TNF alpha protein |
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| 30R-2188 | Fitzgerald | 50 ug | EUR 532 |
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Description: Purified recombinant Human TNF alpha protein |
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TNF alpha protein |
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| 30R-2317 | Fitzgerald | 50 ug | EUR 352 |
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Description: Purified recombinant Human TNF alpha protein |
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TNF alpha protein |
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| 30R-2402 | Fitzgerald | 10 ug | EUR 247 |
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Description: Purified recombinant Human TNF alpha protein |
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TNF alpha protein |
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| 30R-2403 | Fitzgerald | 10 ug | EUR 247 |
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Description: Purified recombinant Human TNF alpha protein |
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Filling the Antibody Pipeline in Allergy: PIPE Cloning of IgE, IgG 1 and IgG 4 against the Major Birch Pollen Allergen Bet v 1
Birch pollen allergy is among the most prevalent pollen allergies in Northern and Central Europe. This IgE-mediated disease can be treated with allergen immunotherapy (AIT), which typically gives rise to IgG antibodies inducing tolerance. Although the main mechanisms of allergen immunotherapy (AIT) are known, questions regarding possible Fc-mediated effects of IgG antibodies remain unanswered.
This can mainly be attributed to the unavailability of appropriate tools, i.e., well-characterised recombinant antibodies (rAbs). We hereby aimed at providing human rAbs of several classes for mechanistic studies and as possible candidates for passive immunotherapy.
We engineered IgE, IgG1, and IgG4 sharing the same variable region against the major birch pollen allergen Bet v 1 using Polymerase Incomplete Primer Extension (PIPE) cloning. We tested IgE functionality and IgG blocking capabilities using appropriate model cell lines.
In vitro studies showed IgE engagement with FcεRI and CD23 and Bet v 1-dependent degranulation. Overall, we hereby present fully functional, human IgE, IgG1, and IgG4 sharing the same variable region against Bet v 1 and showcase possible applications in first mechanistic studies.
Furthermore, our IgG antibodies might be useful candidates for passive immunotherapy of birch pollen allergy.
 LEC antibody |
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| 70R-LG003 | Fitzgerald | 50 ug | EUR 273 |
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Description: Affinity purified Goat polyclonal LEC antibody |
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 Protein) Recombinant Human LEC (CCL16) Protein |
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| PROTO15467-1 | BosterBio | 20ug | EUR 317 |
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Description: LEC is a CC chemokine that can signal through the CCR8 and CCR1 receptors. It is expressed in the liver, spleen, and thymus. LEC is chemotactic towards monocytes and lymphocytes but not neutrophils. Recombinant human LEC is an 11.2 kDa protein containing 97 amino acid residues, including the four conserved cysteine residues present in CC chemokines. |
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 Polyclonal Goat anti-GST α-form |
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| GST-ANTI-1 | Detroit R&D | 50 uL | EUR 280 |
 Polyclonal Goat anti-GST μ-form |
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| GST-ANTI-2 | Detroit R&D | 50 uL | EUR 280 |
 Polyclonal Goat anti-GST p-form |
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| GST-ANTI-3 | Detroit R&D | 50 uL | EUR 280 |
 Antibody) LEC Chemokine(LEC66) Antibody |
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| BNUB0066-100 | Biotium | 100uL | EUR 209 |
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Description: Primary antibody against LEC Chemokine(LEC66), Concentration: 0.2mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNUB0066-500 | Biotium | 500uL | EUR 458 |
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Description: Primary antibody against LEC Chemokine(LEC66), Concentration: 0.2mg/mL |
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 Antibody) LEC Chemokine(LEC67) Antibody |
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| BNUB0067-100 | Biotium | 100uL | EUR 209 |
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Description: Primary antibody against LEC Chemokine(LEC67), Concentration: 0.2mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNUB0067-500 | Biotium | 500uL | EUR 458 |
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Description: Primary antibody against LEC Chemokine(LEC67), Concentration: 0.2mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNUM0066-50 | Biotium | 50uL | EUR 395 |
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Description: Primary antibody against LEC Chemokine(LEC66), 1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNUM0067-50 | Biotium | 50uL | EUR 395 |
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Description: Primary antibody against LEC Chemokine(LEC67), 1mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNC040066-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against LEC Chemokine(LEC66), CF405S conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNC040066-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against LEC Chemokine(LEC66), CF405S conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNC040067-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against LEC Chemokine(LEC67), CF405S conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNC040067-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against LEC Chemokine(LEC67), CF405S conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNC610066-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against LEC Chemokine(LEC66), CF660R conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNC610066-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against LEC Chemokine(LEC66), CF660R conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNC610067-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against LEC Chemokine(LEC67), CF660R conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNC610067-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against LEC Chemokine(LEC67), CF660R conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNC470066-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against LEC Chemokine(LEC66), CF647 conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNC470066-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against LEC Chemokine(LEC66), CF647 conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNC470067-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against LEC Chemokine(LEC67), CF647 conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNC470067-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against LEC Chemokine(LEC67), CF647 conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNC550066-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against LEC Chemokine(LEC66), CF555 conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNC550066-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against LEC Chemokine(LEC66), CF555 conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNC550067-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against LEC Chemokine(LEC67), CF555 conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNC550067-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against LEC Chemokine(LEC67), CF555 conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNC050066-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against LEC Chemokine(LEC66), CF405M conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNC050066-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against LEC Chemokine(LEC66), CF405M conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNC050067-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against LEC Chemokine(LEC67), CF405M conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNC050067-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against LEC Chemokine(LEC67), CF405M conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNC400066-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against LEC Chemokine(LEC66), CF640R conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNC400066-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against LEC Chemokine(LEC66), CF640R conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNC400067-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against LEC Chemokine(LEC67), CF640R conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNC400067-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against LEC Chemokine(LEC67), CF640R conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNC430066-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against LEC Chemokine(LEC66), CF543 conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNC430066-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against LEC Chemokine(LEC66), CF543 conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNC430067-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against LEC Chemokine(LEC67), CF543 conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNC430067-500 | Biotium | 500uL | EUR 544 |
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Description: Primary antibody against LEC Chemokine(LEC67), CF543 conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNC800066-100 | Biotium | 100uL | EUR 199 |
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Description: Primary antibody against LEC Chemokine(LEC66), CF680 conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
|||
| BNC800066-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against LEC Chemokine(LEC66), CF680 conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNC800067-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against LEC Chemokine(LEC67), CF680 conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNC800067-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against LEC Chemokine(LEC67), CF680 conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNC810066-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against LEC Chemokine(LEC66), CF680R conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNC810066-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against LEC Chemokine(LEC66), CF680R conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNC810067-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against LEC Chemokine(LEC67), CF680R conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNC810067-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against LEC Chemokine(LEC67), CF680R conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNCP0066-250 | Biotium | 250uL | EUR 383 |
|
Description: Primary antibody against LEC Chemokine(LEC66), PerCP conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
|||
| BNCP0067-250 | Biotium | 250uL | EUR 383 |
|
Description: Primary antibody against LEC Chemokine(LEC67), PerCP conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNCR0066-250 | Biotium | 250uL | EUR 383 |
|
Description: Primary antibody against LEC Chemokine(LEC66), RPE conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNCR0067-250 | Biotium | 250uL | EUR 383 |
|
Description: Primary antibody against LEC Chemokine(LEC67), RPE conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNCA0066-250 | Biotium | 250uL | EUR 383 |
|
Description: Primary antibody against LEC Chemokine(LEC66), APC conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNCA0067-250 | Biotium | 250uL | EUR 383 |
|
Description: Primary antibody against LEC Chemokine(LEC67), APC conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNCAP0066-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against LEC Chemokine(LEC66), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNCAP0066-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against LEC Chemokine(LEC66), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNCAP0067-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against LEC Chemokine(LEC67), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNCAP0067-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against LEC Chemokine(LEC67), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNCH0066-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against LEC Chemokine(LEC66), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNCH0066-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against LEC Chemokine(LEC66), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNCH0067-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against LEC Chemokine(LEC67), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNCH0067-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against LEC Chemokine(LEC67), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNC940066-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against LEC Chemokine(LEC66), CF594 conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNC940066-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against LEC Chemokine(LEC66), CF594 conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNC940067-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against LEC Chemokine(LEC67), CF594 conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNC940067-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against LEC Chemokine(LEC67), CF594 conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNC700066-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against LEC Chemokine(LEC66), CF770 conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNC700066-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against LEC Chemokine(LEC66), CF770 conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNC700067-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against LEC Chemokine(LEC67), CF770 conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNC700067-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against LEC Chemokine(LEC67), CF770 conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNCB0066-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against LEC Chemokine(LEC66), Biotin conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNCB0066-500 | Biotium | 500uL | EUR 544 |
|
Description: Primary antibody against LEC Chemokine(LEC66), Biotin conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNCB0067-100 | Biotium | 100uL | EUR 199 |
|
Description: Primary antibody against LEC Chemokine(LEC67), Biotin conjugate, Concentration: 0.1mg/mL |
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