genediag
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August 24, 2020

Research for Disulfide-Linked, Self-Immolating Subsequent-Technology Antibody Drug

By Karina

Conjugation Site Influences Antibody-Conjugated Drug PK Assays: Case Studies for Disulfide-Linked, Self-Immolating Next-Generation Antibody Drug Conjugates

 

Immunoaffinity (IA) LC-MS/MS pharmacokinetic (PK) assays are widely used in the field for antibody drug conjugates (ADCs) containing peptide linkers that are enzymatically cleavable, such as MC-ValCit-PAB. Conjugate PK assay strategies for these ADCs involve cleavage with cathepsin B or papain to release and measure the antibody-conjugated drug (acDrug) concentration.
However, robust acDrug PK methods for disulfide-linked self-immolating ADCs are lacking as they are a different conjugation modality. We developed acDrug PK assays for next-generation disulfide-linked ADCs involving immunoaffinity capture, chemical cleavage, and LC-MS/MS. Disulfide-linked ADCs captured from plasma were chemically reduced at basic pH to release the linker-drug, followed by self-immolation to liberate the active drug, and quantified by MRM LC-MS/MS.
Herein, we detail the development and optimization of this chemical cleavage acDrug PK assay, resulting in robust accuracy and precision (<u>+</u>20%). The conjugation site of the linker-drug on the antibody was found to affect the kinetics of drug release.
Multiple biophysical and chemical characteristics, such as tertiary structure, fractional solvent accessibility, pKa of the conjugation site, surrounding residue’s pI, and electrostatic charge, may directly impact the drug release kinetics. Similar site-specific stability has been previously reported for ADCs in vivo.
The assay development and qualification data for this original assay format are presented along with its application to multiple in vitro and in vivo studies across species.

Gestational Dysfunction-Driven Diets and Probiotic Supplementation Correlate with the Profile of Allergen-Specific Antibodies in the Serum of Allergy Sufferers

Background: Maternal diet has significant effects on development of childhood atopic disease and hypersensitivity development. However, the gestational dysfunctions demanding special diets are becoming a widespread phenomenon, their immunological implications can be manifested in the profile of antibodies in the offspring’s serum.
Methods: 153 allergic and 150 healthy individuals were diagnosed for allergy using specific antibody and cytokine immunoassay tests. The medical history of subjects along with mothers’ course of pregnancy was completed by allergologist’s anamnesis. A self-organizing neural network and multivariate analyses to complex data and pick basic interactions were used.
Results: Two significant explanatory modules were determined. The first was formed by gestational diabetic and cholestatic diet, infant formula feeding type, probiotic supplementation and its BMI index, moderate IgE, increased IgG levels of antibodies and single or poly-food allergy type (7 clusters).
The second was formed by gestational vegan/vegetarian and elimination diet, maternal probiotic supplementation, sex, high IgE total antibodies and food and mixed poly-allergy to aero- and food-origin allergens (19 clusters).
Conclusions: Significant associations were observed between special gestational diet intake underlying foetal programming and the mechanisms of childhood allergy. The novelty is the positive association between diabetic and cholestatic diet intake and IgE/IgG-mediated food hypersensitivity.
Keywords: allergic patterns; allergy prevalence; artificial self-organizing neural network; foetal programming; gestational dysfunction-driven diets; probiotics supplementation; specific IgE-antibodies profile.
genediag

genediag

Anti-human TNF-alpha antibody
STJ15100115 250 µg
EUR 367
Description: This monoclonal antibody enables sensitive and specific detection of human TNF-α in Flow cytometry and Western blot.

Anti-human TNF-alpha antibody
STJ15100116 250 µg
EUR 336
Description: We recommend MT25C5 as capture antibody in ELISA and ELISpot in combination with biotinylated detection antibody MT20D9.

Anti-human TNF-alpha antibody
STJ15100117 250 µg
EUR 367
Description: This monoclonal antibody enables sensitive and specific detection of human TNF-α in immunoassays such as ELISA and ELISpot.

anti- TNF alpha antibody
FNab08815 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:5000
  • IHC: 1:200-1:1000
  • Immunogen: tumor necrosis factor(TNF superfamily, member 2)
  • Uniprot ID: P01375
  • Research Area: Signal Transduction, Cardiovascular, Cancer, Immunology, Neuroscience
Description: Antibody raised against TNF alpha

anti- TNF-alpha antibody
FNab08821 100µg
EUR 585
  • Recommended dilution: WB: 1:200-1:1000
  • IHC: 1:50-1:500
  • Immunogen: tumor necrosis factor(TNF superfamily, member 2)
  • Uniprot ID: P01375
  • Research Area: Immunology, Cardiovascular, Developmental biology, Signal Transduction
Description: Antibody raised against TNF-alpha

anti- TNF alpha antibody
FNab09822 100µg
EUR 548.75
  • Recommended dilution: WB: 1:1000 - 1:2000
  • IHC: 1:50 - 1:100
  • Immunogen: tumor necrosis factor (TNF superfamily, member 2)
  • Uniprot ID: P01375
  • Gene ID: 7124
  • Research Area: Signal Transduction, Cardiovascular, Cancer, Immunology, Neuroscience
Description: Antibody raised against TNF alpha

Anti-TNF alpha Antibody
A00002-2 100ug/vial
EUR 294

Anti-TNF alpha Antibody
A00002-3 100ug/vial
EUR 294

Anti-TNF alpha Purified
11-687-C025 0.025 mg
EUR 99

Anti-TNF alpha Purified
11-687-C100 0.1 mg
EUR 158

Anti-TNF alpha Purified
11-688-C025 0.025 mg
EUR 99

Anti-TNF alpha Purified
11-688-C100 0.1 mg
EUR 158

Anti-TNF alpha APC
1A-688-T025 25 tests
EUR 140

Anti-TNF alpha APC
1A-688-T100 100 tests
EUR 240

Anti-TNF alpha FITC
1F-688-T025 25 tests
EUR 122

Anti-TNF alpha FITC
1F-688-T100 100 tests
EUR 204

Anti-TNF alpha PE
1P-688-T025 25 tests
EUR 140

Anti-TNF alpha PE
1P-688-T100 100 tests
EUR 240

Anti-TNF alpha Antibody
PB9246 100ug/vial
EUR 294

Anti-TNF alpha Antibody
PB9010 100ug/vial
EUR 294

Anti-TNF-alpha antibody
PAab08821 100 ug
EUR 412

anti- TNF alpha antibody
LSMab09822 100 ug
EUR 386

anti-TNF-alpha (2A9B9)
LF-MA30138 100 ul
EUR 486
Description: Mouse Monoclonal to TNF-alpha

Anti-TNF alpha Antibody
PA1079 100ug/vial
EUR 334

Anti-TNF alpha antibody
STJ97488 200 µl
EUR 197
Description: Rabbit polyclonal to TNF alpha.

Anti-TNF alpha antibody
STJ97489 200 µl
EUR 197
Description: Rabbit polyclonal to TNF alpha.

Anti-TNF alpha antibody
STJ97493 200 µl
EUR 197
Description: Mouse monoclonal to TNF alpha.

Anti-TNF alpha antibody
STJ97494 200 µl
EUR 197
Description: Mouse monoclonal to TNF alpha.

Anti-TNF-alpha antibody
STJ96054 200 µl
EUR 197
Description: TNF-alpha is a protein encoded by the TNF gene which is approximately 25,6 kDa. TNF-alpha is localised to the cell membrane. It is involved in PEDF induced signalling, TNFR1 pathway, allograft rejection and apoptosis modulation and signalling. It is a cytokine that is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, lipid metabolism, and coagulation. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF-alpha is expressed in the blood, lung, spleen, liver and heart. Mutations in the TNF gene may result in psoriatic arthritis. STJ96054 was affinity purified. This polyclonal antibody binds to endogenous TNF-alpha.

Anti-TNF-alpha antibody
STJ96516 200 µl
EUR 197
Description: Rabbit polyclonal to TNF-alpha.

Anti-TNF alpha antibody
STJ140123 150 µg
EUR 408
Description: Goat polyclonal antibody to TNF alpha. TNF-alpha is produced by a variety of immune cells including NK cells, B cells, T cells and macrophages. It is multifunctional proinflammatory cytokine that belongs to the tumour necrosis factor (TNF) superfamily. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is involved in the regulation of several processes including lipid metabolism cell differentiation and proliferation, coagulation and apoptosis. It has been implicated in a variety of diseases, including cancer and autoimmune diseases.

Anti-TNF-Alpha antibody
STJ16100927 100 µg
EUR 451

Anti-TNF-Alpha antibody
STJ16100932 100 µg
EUR 648

Anti-TNF-Alpha antibody
STJ16100933 50 µg
EUR 531

Anti-TNF-Alpha antibody
STJ16100934 100 µg
EUR 648

Anti-TNF-Alpha antibody
STJ16100935 50 µg
EUR 531

Monoclonal Anti-Human Tumor Necrosis Factor-Alpha (TNF-alpha) IgG #1 aff. Pure
TNFA11-M 100 ug
EUR 482

Monoclonal Anti-Human Tumor Necrosis Factor-Alpha (TNF-alpha) IgG #2, aff. Pure
TNFA12-M 100 ug
EUR 482

Rabbit Anti-Rat TNF-alpha Converting Enzyme (TACE) antiserum
TACE11-S 100 ul
EUR 457

Goat Anti-Human Tumor Necrosis Factor-Alpha (TNF-alpha) IgG #2, aff. Pure (neutralzing)
TNFA13-A 100 ul
EUR 482

Anti-human/monkey TNF-alpha antibody
STJ15100118 250 µg
EUR 336
Description: This monoclonal antibody enables sensitive and specific detection of monkey TNF-α in immunoassays such as ELISA and ELISpot.

Anti-human/monkey TNF-alpha antibody
STJ15100119 250 µg
EUR 367
Description: This monoclonal antibody enables sensitive and specific detection of TNF-α in immunoassays such as ELISA and ELISpot, Flow cytometry, and Western blot.

Anti-mouse TNF alpha Antibody
RP1000 100ug/vial
EUR 334

Anti-mouse TNF-alpha antibody
STJ15100113 250 µg
EUR 336
Description: These monoclonal antibodies enable sensitive and specific detection of mouse TNF-α in immunoassays such as ELISA and ELISpot.

Anti-mouse TNF-alpha antibody
STJ15100114 250 µg
EUR 367
Description: This monoclonal antibody enables sensitive and specific detection of mouse TNF-α in immunoassays such as ELISA and ELISpot.

Anti-Mouse TNF-alpha antibody
STJ16100926 100 µg
EUR 701

Anti-Mouse TNF-alpha antibody
STJ16101171 1 mL
EUR 801

Anti-TNF alpha (M2-E3)
YF-MA15915 100 ug
EUR 363
Description: Mouse monoclonal to TNF alpha

Anti-TNF alpha (M1-C4)
YF-MA10949 100 ug
EUR 363
Description: Mouse monoclonal to TNF alpha

Human TNF-alpha ELISA Kit, 96 tests, Quantitative
100-215-TNH 1 kit
EUR 482

TNF alpha
GT15064 100 ug
EUR 526

TNF alpha
GT15113 100 ug
EUR 526

TNF-alpha
PR27146 50 ug
EUR 318

Rabbit Anti-Rat TNF-alpha Converting Enzyme (TACE), IgG aff. Pure
TACE11-A 100 ug
EUR 482

Human anti TNF Alpha autoantibody ELISA kit
E01A2132-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Human anti TNF Alpha autoantibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human anti TNF Alpha autoantibody ELISA kit
E01A2132-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Human anti TNF Alpha autoantibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human anti TNF Alpha autoantibody ELISA kit
E01A2132-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Human anti TNF Alpha autoantibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Anti-TNF alpha (Humicade), Human IgG4 Antibody
A1093-200
EUR 729

Anti-TNF alpha (Infliximab), Human IgG1 Antibody
A1097-200
EUR 778

Recombinant (E.Coli) purified human Tumor Necrosis Factor-Alpha (TNF-alpha), biologically active
TNFA15-R-10 10 ug
EUR 225

Anti-TNF-alpha Antibody Clone TNF/1500R, Unconjugated-20ug
7124-RBM13-P0 20ug
EUR 233

Anti-TNF-alpha Antibody Clone TNF/1500R, Unconjugated-100ug
7124-RBM13-P1 100ug
EUR 428

Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN 50 µg
EUR 349

TruStrip RDT Humira/Adalimumab (anti-TNF-alpha) Rapid Test cards, 10/pk
200-320-RDT 1 pk
EUR 293

TNF-alpha/TNFSF2, Human
HY-P7058 100ug
EUR 441

Human TNF alpha Protein
abx060828-005mg 0.05 mg
EUR 551
  • Shipped within 5-10 working days.

TNF-alpha, human recombinant
1050-10
EUR 153

TNF-alpha, human recombinant
1050-1000
EUR 1751

TNF-alpha, human recombinant
1050-50
EUR 283

Human TNF-alpha Antibody
13101-05011 150 ug
EUR 217

Human TNF-alpha antibody
32809-05111 150 ug
EUR 261

Anti-TNF alpha Purified Azide Free
10-687-C100 0.1 mg
EUR 158

Anti-TNF alpha (1C3-A1-F4)
YF-MA15914 100 ug
EUR 363
Description: Mouse monoclonal to TNF alpha

rHu TNF-alpha
AK8324-0010 10µg Ask for price

rHu TNF-alpha
AK8324-0050 50µg Ask for price

rHu TNF-alpha
AK8324-0100 100µg Ask for price

rHu TNF-alpha
AK8324-1000 1mg Ask for price

TNF-alpha Antibody
BF0170 200ul
EUR 376
Description: TNF-alpha antibody detects endogenous levels of total TNF-alpha.

TNF-alpha, Bovine
HY-P7302 50ug
EUR 533

TNF alpha Protein
20-abx261608
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.

TNF alpha Protein
20-abx261626
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.

TNF alpha Protein
20-abx261641
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.

TNF alpha Protein
20-abx261652
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.

Filling the Antibody Pipeline in Allergy: PIPE Cloning of IgE, IgG 1 and IgG 4 against the Major Birch Pollen Allergen Bet v 1

 

Birch pollen allergy is among the most prevalent pollen allergies in Northern and Central Europe. This IgE-mediated disease can be treated with allergen immunotherapy (AIT), which typically gives rise to IgG antibodies inducing tolerance. Although the main mechanisms of allergen immunotherapy (AIT) are known, questions regarding possible Fc-mediated effects of IgG antibodies remain unanswered.
This can mainly be attributed to the unavailability of appropriate tools, i.e., well-characterised recombinant antibodies (rAbs). We hereby aimed at providing human rAbs of several classes for mechanistic studies and as possible candidates for passive immunotherapy.
We engineered IgE, IgG1, and IgG4 sharing the same variable region against the major birch pollen allergen Bet v 1 using Polymerase Incomplete Primer Extension (PIPE) cloning. We tested IgE functionality and IgG blocking capabilities using appropriate model cell lines.
In vitro studies showed IgE engagement with FcεRI and CD23 and Bet v 1-dependent degranulation. Overall, we hereby present fully functional, human IgE, IgG1, and IgG4 sharing the same variable region against Bet v 1 and showcase possible applications in first mechanistic studies.
Furthermore, our IgG antibodies might be useful candidates for passive immunotherapy of birch pollen allergy.

LEC protein
30R-AL013 20 ug
EUR 273
Description: Purified recombinant Human LEC protein

Recombinant Human LEC (CCL16) Protein
PROTO15467-1 20ug
EUR 317
Description: LEC is a CC chemokine that can signal through the CCR8 and CCR1 receptors. It is expressed in the liver, spleen, and thymus. LEC is chemotactic towards monocytes and lymphocytes but not neutrophils. Recombinant human LEC is an 11.2 kDa protein containing 97 amino acid residues, including the four conserved cysteine residues present in CC chemokines.

Polyclonal Goat anti-GST α-form
GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST μ-form
GST-ANTI-2 50 uL
EUR 280

Polyclonal Goat anti-GST p-form
GST-ANTI-3 50 uL
EUR 280

LEC Chemokine(LEC66) Antibody
BNC610066-100 100uL
EUR 199
Description: Primary antibody against LEC Chemokine(LEC66), CF660R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC610066-500 500uL
EUR 544
Description: Primary antibody against LEC Chemokine(LEC66), CF660R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC610067-100 100uL
EUR 199
Description: Primary antibody against LEC Chemokine(LEC67), CF660R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC610067-500 500uL
EUR 544
Description: Primary antibody against LEC Chemokine(LEC67), CF660R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC680066-100 100uL
EUR 199
Description: Primary antibody against LEC Chemokine(LEC66), CF568 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC680066-500 500uL
EUR 544
Description: Primary antibody against LEC Chemokine(LEC66), CF568 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC680067-100 100uL
EUR 199
Description: Primary antibody against LEC Chemokine(LEC67), CF568 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC680067-500 500uL
EUR 544
Description: Primary antibody against LEC Chemokine(LEC67), CF568 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC430066-100 100uL
EUR 199
Description: Primary antibody against LEC Chemokine(LEC66), CF543 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC430066-500 500uL
EUR 544
Description: Primary antibody against LEC Chemokine(LEC66), CF543 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC430067-100 100uL
EUR 199
Description: Primary antibody against LEC Chemokine(LEC67), CF543 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC430067-500 500uL
EUR 544
Description: Primary antibody against LEC Chemokine(LEC67), CF543 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC550066-100 100uL
EUR 199
Description: Primary antibody against LEC Chemokine(LEC66), CF555 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC550066-500 500uL
EUR 544
Description: Primary antibody against LEC Chemokine(LEC66), CF555 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC550067-100 100uL
EUR 199
Description: Primary antibody against LEC Chemokine(LEC67), CF555 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC550067-500 500uL
EUR 544
Description: Primary antibody against LEC Chemokine(LEC67), CF555 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC040066-100 100uL
EUR 199
Description: Primary antibody against LEC Chemokine(LEC66), CF405S conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC040066-500 500uL
EUR 544
Description: Primary antibody against LEC Chemokine(LEC66), CF405S conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC040067-100 100uL
EUR 199
Description: Primary antibody against LEC Chemokine(LEC67), CF405S conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC040067-500 500uL
EUR 544
Description: Primary antibody against LEC Chemokine(LEC67), CF405S conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC400066-100 100uL
EUR 199
Description: Primary antibody against LEC Chemokine(LEC66), CF640R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC400066-500 500uL
EUR 544
Description: Primary antibody against LEC Chemokine(LEC66), CF640R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC400067-100 100uL
EUR 199
Description: Primary antibody against LEC Chemokine(LEC67), CF640R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC400067-500 500uL
EUR 544
Description: Primary antibody against LEC Chemokine(LEC67), CF640R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC050066-100 100uL
EUR 199
Description: Primary antibody against LEC Chemokine(LEC66), CF405M conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC050066-500 500uL
EUR 544
Description: Primary antibody against LEC Chemokine(LEC66), CF405M conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC050067-100 100uL
EUR 199
Description: Primary antibody against LEC Chemokine(LEC67), CF405M conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC050067-500 500uL
EUR 544
Description: Primary antibody against LEC Chemokine(LEC67), CF405M conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC470066-100 100uL
EUR 199
Description: Primary antibody against LEC Chemokine(LEC66), CF647 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC470066-500 500uL
EUR 544
Description: Primary antibody against LEC Chemokine(LEC66), CF647 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC470067-100 100uL
EUR 199
Description: Primary antibody against LEC Chemokine(LEC67), CF647 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC470067-500 500uL
EUR 544
Description: Primary antibody against LEC Chemokine(LEC67), CF647 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNUM0066-50 50uL
EUR 395
Description: Primary antibody against LEC Chemokine(LEC66), 1mg/mL

LEC Chemokine(LEC67) Antibody
BNUM0067-50 50uL
EUR 395
Description: Primary antibody against LEC Chemokine(LEC67), 1mg/mL

LEC Chemokine(LEC66) Antibody
BNC700066-100 100uL
EUR 199
Description: Primary antibody against LEC Chemokine(LEC66), CF770 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC700066-500 500uL
EUR 544
Description: Primary antibody against LEC Chemokine(LEC66), CF770 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC700067-100 100uL
EUR 199
Description: Primary antibody against LEC Chemokine(LEC67), CF770 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC700067-500 500uL
EUR 544
Description: Primary antibody against LEC Chemokine(LEC67), CF770 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC940066-100 100uL
EUR 199
Description: Primary antibody against LEC Chemokine(LEC66), CF594 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC940066-500 500uL
EUR 544
Description: Primary antibody against LEC Chemokine(LEC66), CF594 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC940067-100 100uL
EUR 199
Description: Primary antibody against LEC Chemokine(LEC67), CF594 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC940067-500 500uL
EUR 544
Description: Primary antibody against LEC Chemokine(LEC67), CF594 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNCA0066-250 250uL
EUR 383
Description: Primary antibody against LEC Chemokine(LEC66), APC conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNCA0067-250 250uL
EUR 383
Description: Primary antibody against LEC Chemokine(LEC67), APC conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNCH0066-100 100uL
EUR 199
Description: Primary antibody against LEC Chemokine(LEC66), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNCH0066-500 500uL
EUR 544
Description: Primary antibody against LEC Chemokine(LEC66), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNCH0067-100 100uL
EUR 199
Description: Primary antibody against LEC Chemokine(LEC67), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNCH0067-500 500uL
EUR 544
Description: Primary antibody against LEC Chemokine(LEC67), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC800066-100 100uL
EUR 199
Description: Primary antibody against LEC Chemokine(LEC66), CF680 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC800066-500 500uL
EUR 544
Description: Primary antibody against LEC Chemokine(LEC66), CF680 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC800067-100 100uL
EUR 199
Description: Primary antibody against LEC Chemokine(LEC67), CF680 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC800067-500 500uL
EUR 544
Description: Primary antibody against LEC Chemokine(LEC67), CF680 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC810066-100 100uL
EUR 199
Description: Primary antibody against LEC Chemokine(LEC66), CF680R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC810066-500 500uL
EUR 544
Description: Primary antibody against LEC Chemokine(LEC66), CF680R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC810067-100 100uL
EUR 199
Description: Primary antibody against LEC Chemokine(LEC67), CF680R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC810067-500 500uL
EUR 544
Description: Primary antibody against LEC Chemokine(LEC67), CF680R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNCP0066-250 250uL
EUR 383
Description: Primary antibody against LEC Chemokine(LEC66), PerCP conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNCP0067-250 250uL
EUR 383
Description: Primary antibody against LEC Chemokine(LEC67), PerCP conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNCR0066-250 250uL
EUR 383
Description: Primary antibody against LEC Chemokine(LEC66), RPE conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNCR0067-250 250uL
EUR 383
Description: Primary antibody against LEC Chemokine(LEC67), RPE conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNCAP0066-100 100uL
EUR 199
Description: Primary antibody against LEC Chemokine(LEC66), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNCAP0066-500 500uL
EUR 544
Description: Primary antibody against LEC Chemokine(LEC66), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNCAP0067-100 100uL
EUR 199
Description: Primary antibody against LEC Chemokine(LEC67), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNCAP0067-500 500uL
EUR 544
Description: Primary antibody against LEC Chemokine(LEC67), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNCB0066-100 100uL
EUR 199
Description: Primary antibody against LEC Chemokine(LEC66), Biotin conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNCB0066-500 500uL
EUR 544
Description: Primary antibody against LEC Chemokine(LEC66), Biotin conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNCB0067-100 100uL
EUR 199
Description: Primary antibody against LEC Chemokine(LEC67), Biotin conjugate, Concentration: 0.1mg/mL
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