August 24, 2020
Research for Disulfide-Linked, Self-Immolating Subsequent-Technology Antibody Drug
Conjugation Site Influences Antibody-Conjugated Drug PK Assays: Case Studies for Disulfide-Linked, Self-Immolating Next-Generation Antibody Drug Conjugates
Immunoaffinity (IA) LC-MS/MS pharmacokinetic (PK) assays are widely used in the field for antibody drug conjugates (ADCs) containing peptide linkers that are enzymatically cleavable, such as MC-ValCit-PAB. Conjugate PK assay strategies for these ADCs involve cleavage with cathepsin B or papain to release and measure the antibody-conjugated drug (acDrug) concentration.
However, robust acDrug PK methods for disulfide-linked self-immolating ADCs are lacking as they are a different conjugation modality. We developed acDrug PK assays for next-generation disulfide-linked ADCs involving immunoaffinity capture, chemical cleavage, and LC-MS/MS. Disulfide-linked ADCs captured from plasma were chemically reduced at basic pH to release the linker-drug, followed by self-immolation to liberate the active drug, and quantified by MRM LC-MS/MS.
Herein, we detail the development and optimization of this chemical cleavage acDrug PK assay, resulting in robust accuracy and precision (<u>+</u>20%). The conjugation site of the linker-drug on the antibody was found to affect the kinetics of drug release.
Multiple biophysical and chemical characteristics, such as tertiary structure, fractional solvent accessibility, pKa of the conjugation site, surrounding residue’s pI, and electrostatic charge, may directly impact the drug release kinetics. Similar site-specific stability has been previously reported for ADCs in vivo.
The assay development and qualification data for this original assay format are presented along with its application to multiple in vitro and in vivo studies across species.
Gestational Dysfunction-Driven Diets and Probiotic Supplementation Correlate with the Profile of Allergen-Specific Antibodies in the Serum of Allergy Sufferers
Background: Maternal diet has significant effects on development of childhood atopic disease and hypersensitivity development. However, the gestational dysfunctions demanding special diets are becoming a widespread phenomenon, their immunological implications can be manifested in the profile of antibodies in the offspring’s serum.
Methods: 153 allergic and 150 healthy individuals were diagnosed for allergy using specific antibody and cytokine immunoassay tests. The medical history of subjects along with mothers’ course of pregnancy was completed by allergologist’s anamnesis. A self-organizing neural network and multivariate analyses to complex data and pick basic interactions were used.
Results: Two significant explanatory modules were determined. The first was formed by gestational diabetic and cholestatic diet, infant formula feeding type, probiotic supplementation and its BMI index, moderate IgE, increased IgG levels of antibodies and single or poly-food allergy type (7 clusters).
The second was formed by gestational vegan/vegetarian and elimination diet, maternal probiotic supplementation, sex, high IgE total antibodies and food and mixed poly-allergy to aero- and food-origin allergens (19 clusters).
Conclusions: Significant associations were observed between special gestational diet intake underlying foetal programming and the mechanisms of childhood allergy. The novelty is the positive association between diabetic and cholestatic diet intake and IgE/IgG-mediated food hypersensitivity.
Keywords: allergic patterns; allergy prevalence; artificial self-organizing neural network; foetal programming; gestational dysfunction-driven diets; probiotics supplementation; specific IgE-antibodies profile.
genediag
Anti-human TNF-alpha antibody |
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| STJ15100117 | St John's Laboratory | 250 µg | EUR 440.4 |
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Description: This monoclonal antibody enables sensitive and specific detection of human TNF-α in immunoassays such as ELISA and ELISpot. |
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Monoclonal Anti-Human Tumor Necrosis Factor-Alpha (TNF-alpha) IgG #1 aff. Pure |
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| TNFA11-M | Alpha Diagnostics | 100 ug | EUR 578.4 |
Monoclonal Anti-Human Tumor Necrosis Factor-Alpha (TNF-alpha) IgG #2, aff. Pure |
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| TNFA12-M | Alpha Diagnostics | 100 ug | EUR 578.4 |
Anti-TNF alpha Purified |
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| 11-687-C025 | ExBio | 0.025 mg | EUR 118.8 |
Anti-TNF alpha Purified |
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| 11-687-C100 | ExBio | 0.1 mg | EUR 189.6 |
Anti-TNF alpha Purified |
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| 11-688-C025 | ExBio | 0.025 mg | EUR 118.8 |
Anti-TNF alpha Purified |
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| 11-688-C100 | ExBio | 0.1 mg | EUR 189.6 |
Anti-TNF alpha APC |
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| 1A-688-T025 | ExBio | 25 tests | EUR 168 |
Anti-TNF alpha APC |
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| 1A-688-T100 | ExBio | 100 tests | EUR 288 |
Anti-TNF alpha FITC |
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| 1F-688-T025 | ExBio | 25 tests | EUR 146.4 |
Anti-TNF alpha FITC |
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| 1F-688-T100 | ExBio | 100 tests | EUR 244.8 |
Anti-TNF alpha PE |
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| 1P-688-T025 | ExBio | 25 tests | EUR 168 |
Anti-TNF alpha PE |
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| 1P-688-T100 | ExBio | 100 tests | EUR 288 |
Anti-TNF alpha Antibody |
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| A00002-2 | BosterBio | 100ug/vial | EUR 352.8 |
Anti-TNF alpha Antibody |
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| A00002-3 | BosterBio | 100ug/vial | EUR 352.8 |
Anti-TNF-alpha antibody |
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| PAab08821 | Lifescience Market | 100 ug | EUR 494.4 |
anti- TNF alpha antibody |
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| LSMab09822 | Lifescience Market | 100 ug | EUR 463.2 |
anti-TNF-alpha (2A9B9) |
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| LF-MA30138 | Abfrontier | 100 ul | EUR 583.2 |
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Description: Mouse Monoclonal to TNF-alpha |
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anti- TNF alpha antibody |
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| FNab08815 | FN Test | 100µg | EUR 702 |
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Description: Antibody raised against TNF alpha |
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anti- TNF-alpha antibody |
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| FNab08821 | FN Test | 100µg | EUR 702 |
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Description: Antibody raised against TNF-alpha |
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anti- TNF alpha antibody |
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| FNab09822 | FN Test | 100µg | EUR 658.5 |
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Description: Antibody raised against TNF alpha |
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Anti-TNF alpha Antibody |
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| PA1079 | BosterBio | 100ug/vial | EUR 400.8 |
Anti-TNF alpha Antibody |
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| PB9010 | BosterBio | 100ug/vial | EUR 352.8 |
Anti-TNF alpha Antibody |
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| PB9246 | BosterBio | 100ug/vial | EUR 352.8 |
Anti-TNF-alpha antibody |
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| STJ96054 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: TNF-alpha is a protein encoded by the TNF gene which is approximately 25,6 kDa. TNF-alpha is localised to the cell membrane. It is involved in PEDF induced signalling, TNFR1 pathway, allograft rejection and apoptosis modulation and signalling. It is a cytokine that is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, lipid metabolism, and coagulation. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF-alpha is expressed in the blood, lung, spleen, liver and heart. Mutations in the TNF gene may result in psoriatic arthritis. STJ96054 was affinity purified. This polyclonal antibody binds to endogenous TNF-alpha. |
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Anti-TNF-alpha antibody |
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| STJ96516 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: Rabbit polyclonal to TNF-alpha. |
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Anti-TNF alpha antibody |
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| STJ97488 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: Rabbit polyclonal to TNF alpha. |
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Anti-TNF alpha antibody |
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| STJ97489 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: Rabbit polyclonal to TNF alpha. |
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Anti-TNF alpha antibody |
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| STJ97493 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: Mouse monoclonal to TNF alpha. |
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Anti-TNF alpha antibody |
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| STJ97494 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: Mouse monoclonal to TNF alpha. |
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Anti-TNF alpha antibody |
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| STJ140123 | St John's Laboratory | 150 µg | EUR 489.6 |
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Description: Goat polyclonal antibody to TNF alpha. TNF-alpha is produced by a variety of immune cells including NK cells, B cells, T cells and macrophages. It is multifunctional proinflammatory cytokine that belongs to the tumour necrosis factor (TNF) superfamily. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is involved in the regulation of several processes including lipid metabolism cell differentiation and proliferation, coagulation and apoptosis. It has been implicated in a variety of diseases, including cancer and autoimmune diseases. |
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Anti-TNF-Alpha antibody |
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| STJ16100927 | St John's Laboratory | 100 µg | EUR 541.2 |
Anti-TNF-Alpha antibody |
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| STJ16100932 | St John's Laboratory | 100 µg | EUR 777.6 |
Anti-TNF-Alpha antibody |
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| STJ16100933 | St John's Laboratory | 50 µg | EUR 637.2 |
Anti-TNF-Alpha antibody |
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| STJ16100934 | St John's Laboratory | 100 µg | EUR 777.6 |
Anti-TNF-Alpha antibody |
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| STJ16100935 | St John's Laboratory | 50 µg | EUR 637.2 |
Rabbit Anti-Rat TNF-alpha Converting Enzyme (TACE) antiserum |
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| TACE11-S | Alpha Diagnostics | 100 ul | EUR 548.4 |
Goat Anti-Human Tumor Necrosis Factor-Alpha (TNF-alpha) IgG #2, aff. Pure (neutralzing) |
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| TNFA13-A | Alpha Diagnostics | 100 ul | EUR 578.4 |
Anti-human/monkey TNF-alpha antibody |
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| STJ15100118 | St John's Laboratory | 250 µg | EUR 403.2 |
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Description: This monoclonal antibody enables sensitive and specific detection of monkey TNF-α in immunoassays such as ELISA and ELISpot. |
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Anti-human/monkey TNF-alpha antibody |
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| STJ15100119 | St John's Laboratory | 250 µg | EUR 440.4 |
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Description: This monoclonal antibody enables sensitive and specific detection of TNF-α in immunoassays such as ELISA and ELISpot, Flow cytometry, and Western blot. |
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Human TNF-alpha ELISA Kit, 96 tests, Quantitative |
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| 100-215-TNH | Alpha Diagnostics | 1 kit | EUR 578.4 |
TNF alpha |
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| GT15064 | Neuromics | 100 ug | EUR 631.2 |
TNF alpha |
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| GT15113 | Neuromics | 100 ug | EUR 631.2 |
TNF-alpha |
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| PR27146 | Neuromics | 50 ug | EUR 381.6 |
Anti-mouse TNF-alpha antibody |
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| STJ15100113 | St John's Laboratory | 250 µg | EUR 403.2 |
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Description: These monoclonal antibodies enable sensitive and specific detection of mouse TNF-α in immunoassays such as ELISA and ELISpot. |
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Anti-mouse TNF-alpha antibody |
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| STJ15100114 | St John's Laboratory | 250 µg | EUR 440.4 |
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Description: This monoclonal antibody enables sensitive and specific detection of mouse TNF-α in immunoassays such as ELISA and ELISpot. |
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Anti-Mouse TNF-alpha antibody |
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| STJ16100926 | St John's Laboratory | 100 µg | EUR 841.2 |
Anti-Mouse TNF-alpha antibody |
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| STJ16101171 | St John's Laboratory | 1 mL | EUR 961.2 |
Anti-TNF alpha (M2-E3) |
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| YF-MA15915 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to TNF alpha |
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Anti-mouse TNF alpha Antibody |
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| RP1000 | BosterBio | 100ug/vial | EUR 400.8 |
Anti-TNF alpha (M1-C4) |
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| YF-MA10949 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to TNF alpha |
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Rabbit Anti-Rat TNF-alpha Converting Enzyme (TACE), IgG aff. Pure |
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| TACE11-A | Alpha Diagnostics | 100 ug | EUR 578.4 |
Recombinant (E.Coli) purified human Tumor Necrosis Factor-Alpha (TNF-alpha), biologically active |
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| TNFA15-R-10 | Alpha Diagnostics | 10 ug | EUR 270 |
Rabbit Polyclonal antibody Anti-CRBN |
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| Anti-CRBN | ImmunoStep | 50 µg | EUR 418.8 |
Human TNF-alpha Antibody |
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| 13101-05011 | AssayPro | 150 ug | EUR 260.4 |
Human TNF-alpha antibody |
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| 32809-05111 | AssayPro | 150 ug | EUR 313.2 |
TNF-alpha, human recombinant |
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| 1050-10 | Biovision | EUR 183.6 | |
TNF-alpha, human recombinant |
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| 1050-1000 | Biovision | EUR 2101.2 | |
TNF-alpha, human recombinant |
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| 1050-50 | Biovision | EUR 339.6 | |
Human TNF alpha Protein |
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| abx060828-005mg | Abbexa | 0.05 mg | EUR 661.2 |
TNF-alpha/TNFSF2, Human |
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| HY-P7058 | MedChemExpress | 100ug | EUR 529.2 |
Anti-TNF alpha (Humicade), Human IgG4 Antibody |
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| A1093-200 | Biovision | EUR 874.8 | |
Anti-TNF alpha (Infliximab), Human IgG1 Antibody |
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| A1097-200 | Biovision | EUR 933.6 | |
Human anti TNF Alpha autoantibody ELISA kit |
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| E01A2132-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A sandwich ELISA for quantitative measurement of Human anti TNF Alpha autoantibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human anti TNF Alpha autoantibody ELISA kit |
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| E01A2132-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A sandwich ELISA for quantitative measurement of Human anti TNF Alpha autoantibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human anti TNF Alpha autoantibody ELISA kit |
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| E01A2132-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A sandwich ELISA for quantitative measurement of Human anti TNF Alpha autoantibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Anti-TNF-alpha Antibody Clone TNF/1500R, Unconjugated-20ug |
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| 7124-RBM13-P0 | EnQuireBio | 20ug | EUR 279.6 |
Anti-TNF-alpha Antibody Clone TNF/1500R, Unconjugated-100ug |
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| 7124-RBM13-P1 | EnQuireBio | 100ug | EUR 513.6 |
TruStrip RDT Humira/Adalimumab (anti-TNF-alpha) Rapid Test cards, 10/pk |
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| 200-320-RDT | Alpha Diagnostics | 1 pk | EUR 351.6 |
Anti-TNF alpha Purified Azide Free |
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| 10-687-C100 | ExBio | 0.1 mg | EUR 189.6 |
Anti-TNF alpha (1C3-A1-F4) |
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| YF-MA15914 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to TNF alpha |
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TNF alpha antibody |
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| 70R-11582 | Fitzgerald | 100 ug | EUR 483.6 |
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Description: Rabbit polyclonal TNF alpha antibody |
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TNF alpha antibody |
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| 70R-11583 | Fitzgerald | 100 ug | EUR 483.6 |
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Description: Rabbit polyclonal TNF alpha antibody |
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TNF alpha antibody |
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| 70R-11584 | Fitzgerald | 100 ug | EUR 483.6 |
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Description: Rabbit polyclonal TNF alpha antibody |
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TNF alpha antibody |
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| 10-T60A | Fitzgerald | 1 mg | EUR 159.6 |
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Description: Mouse monoclonal TNF alpha antibody |
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TNF alpha antibody |
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| 10-T60B | Fitzgerald | 1 mg | EUR 536.4 |
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Description: Mouse monoclonal TNF alpha antibody |
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TNF alpha antibody |
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| 10-T60C | Fitzgerald | 1 mg | EUR 536.4 |
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Description: Mouse monoclonal TNF alpha antibody |
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TNF alpha antibody |
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| 10-T60D | Fitzgerald | 1 mg | EUR 522 |
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Description: Mouse monoclonal TNF alpha antibody |
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TNF alpha antibody |
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| 10R-8493 | Fitzgerald | 100 ul | EUR 471.6 |
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Description: Mouse monoclonal TNF alpha antibody |
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TNF alpha antibody |
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| 70R-50493 | Fitzgerald | 100 ul | EUR 292.8 |
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Description: Purified Polyclonal TNF alpha antibody |
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TNF alpha antibody |
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| 70R-13663 | Fitzgerald | 100 ug | EUR 457.2 |
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Description: Affinity purified Rabbit polyclonal TNF alpha antibody |
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TNF-alpha Antibody |
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| 3052R-100 | Biovision | EUR 379.2 | |
TNF-alpha Antibody |
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| 3052R-30T | Biovision | EUR 175.2 | |
Filling the Antibody Pipeline in Allergy: PIPE Cloning of IgE, IgG 1 and IgG 4 against the Major Birch Pollen Allergen Bet v 1
Birch pollen allergy is among the most prevalent pollen allergies in Northern and Central Europe. This IgE-mediated disease can be treated with allergen immunotherapy (AIT), which typically gives rise to IgG antibodies inducing tolerance. Although the main mechanisms of allergen immunotherapy (AIT) are known, questions regarding possible Fc-mediated effects of IgG antibodies remain unanswered.
This can mainly be attributed to the unavailability of appropriate tools, i.e., well-characterised recombinant antibodies (rAbs). We hereby aimed at providing human rAbs of several classes for mechanistic studies and as possible candidates for passive immunotherapy.
We engineered IgE, IgG1, and IgG4 sharing the same variable region against the major birch pollen allergen Bet v 1 using Polymerase Incomplete Primer Extension (PIPE) cloning. We tested IgE functionality and IgG blocking capabilities using appropriate model cell lines.
In vitro studies showed IgE engagement with FcεRI and CD23 and Bet v 1-dependent degranulation. Overall, we hereby present fully functional, human IgE, IgG1, and IgG4 sharing the same variable region against Bet v 1 and showcase possible applications in first mechanistic studies.
Furthermore, our IgG antibodies might be useful candidates for passive immunotherapy of birch pollen allergy.
Polyclonal Goat anti-GST α-form |
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| GST-ANTI-1 | Detroit R&D | 50 uL | EUR 336 |
Polyclonal Goat anti-GST μ-form |
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| GST-ANTI-2 | Detroit R&D | 50 uL | EUR 336 |
Polyclonal Goat anti-GST p-form |
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| GST-ANTI-3 | Detroit R&D | 50 uL | EUR 336 |
LEC Chemokine(LEC66) Antibody |
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| BNCA0066-250 | Biotium | 250uL | EUR 459.6 |
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Description: Primary antibody against LEC Chemokine(LEC66), APC conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNCA0067-250 | Biotium | 250uL | EUR 459.6 |
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Description: Primary antibody against LEC Chemokine(LEC67), APC conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNCAP0066-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against LEC Chemokine(LEC66), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNCAP0066-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against LEC Chemokine(LEC66), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNCAP0067-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against LEC Chemokine(LEC67), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNCAP0067-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against LEC Chemokine(LEC67), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNC610066-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against LEC Chemokine(LEC66), CF660R conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNC610066-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against LEC Chemokine(LEC66), CF660R conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNC610067-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against LEC Chemokine(LEC67), CF660R conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNC610067-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against LEC Chemokine(LEC67), CF660R conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNC680066-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against LEC Chemokine(LEC66), CF568 conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNC680066-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against LEC Chemokine(LEC66), CF568 conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNC680067-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against LEC Chemokine(LEC67), CF568 conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNC680067-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against LEC Chemokine(LEC67), CF568 conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNCR0066-250 | Biotium | 250uL | EUR 459.6 |
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Description: Primary antibody against LEC Chemokine(LEC66), RPE conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNCR0067-250 | Biotium | 250uL | EUR 459.6 |
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Description: Primary antibody against LEC Chemokine(LEC67), RPE conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNUB0066-100 | Biotium | 100uL | EUR 250.8 |
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Description: Primary antibody against LEC Chemokine(LEC66), Concentration: 0.2mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNUB0066-500 | Biotium | 500uL | EUR 549.6 |
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Description: Primary antibody against LEC Chemokine(LEC66), Concentration: 0.2mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNUB0067-100 | Biotium | 100uL | EUR 250.8 |
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Description: Primary antibody against LEC Chemokine(LEC67), Concentration: 0.2mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNUB0067-500 | Biotium | 500uL | EUR 549.6 |
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Description: Primary antibody against LEC Chemokine(LEC67), Concentration: 0.2mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNC430066-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against LEC Chemokine(LEC66), CF543 conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNC430066-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against LEC Chemokine(LEC66), CF543 conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNC430067-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against LEC Chemokine(LEC67), CF543 conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNC430067-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against LEC Chemokine(LEC67), CF543 conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNC470066-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against LEC Chemokine(LEC66), CF647 conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNC470066-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against LEC Chemokine(LEC66), CF647 conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNC470067-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against LEC Chemokine(LEC67), CF647 conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNC470067-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against LEC Chemokine(LEC67), CF647 conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNC400066-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against LEC Chemokine(LEC66), CF640R conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNC400066-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against LEC Chemokine(LEC66), CF640R conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNC400067-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against LEC Chemokine(LEC67), CF640R conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNC400067-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against LEC Chemokine(LEC67), CF640R conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNC880066-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against LEC Chemokine(LEC66), CF488A conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
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| BNC880066-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against LEC Chemokine(LEC66), CF488A conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNC880067-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against LEC Chemokine(LEC67), CF488A conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC67) Antibody |
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| BNC880067-500 | Biotium | 500uL | EUR 652.8 |
|
Description: Primary antibody against LEC Chemokine(LEC67), CF488A conjugate, Concentration: 0.1mg/mL |
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LEC Chemokine(LEC66) Antibody |
|||
| BNC810066-100 | Biotium | 100uL | EUR 238.8 |
|
Description: Primary antibody against LEC Chemokine(LEC66), CF680R conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNC810066-500 | Biotium | 500uL | EUR 652.8 |
|
Description: Primary antibody against LEC Chemokine(LEC66), CF680R conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNC810067-100 | Biotium | 100uL | EUR 238.8 |
|
Description: Primary antibody against LEC Chemokine(LEC67), CF680R conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNC810067-500 | Biotium | 500uL | EUR 652.8 |
|
Description: Primary antibody against LEC Chemokine(LEC67), CF680R conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNCP0066-250 | Biotium | 250uL | EUR 459.6 |
|
Description: Primary antibody against LEC Chemokine(LEC66), PerCP conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNCP0067-250 | Biotium | 250uL | EUR 459.6 |
|
Description: Primary antibody against LEC Chemokine(LEC67), PerCP conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNUM0066-50 | Biotium | 50uL | EUR 474 |
|
Description: Primary antibody against LEC Chemokine(LEC66), 1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNUM0067-50 | Biotium | 50uL | EUR 474 |
|
Description: Primary antibody against LEC Chemokine(LEC67), 1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNC050066-100 | Biotium | 100uL | EUR 238.8 |
|
Description: Primary antibody against LEC Chemokine(LEC66), CF405M conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNC050066-500 | Biotium | 500uL | EUR 652.8 |
|
Description: Primary antibody against LEC Chemokine(LEC66), CF405M conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNC050067-100 | Biotium | 100uL | EUR 238.8 |
|
Description: Primary antibody against LEC Chemokine(LEC67), CF405M conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNC050067-500 | Biotium | 500uL | EUR 652.8 |
|
Description: Primary antibody against LEC Chemokine(LEC67), CF405M conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNC700066-100 | Biotium | 100uL | EUR 238.8 |
|
Description: Primary antibody against LEC Chemokine(LEC66), CF770 conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNC700066-500 | Biotium | 500uL | EUR 652.8 |
|
Description: Primary antibody against LEC Chemokine(LEC66), CF770 conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNC700067-100 | Biotium | 100uL | EUR 238.8 |
|
Description: Primary antibody against LEC Chemokine(LEC67), CF770 conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNC700067-500 | Biotium | 500uL | EUR 652.8 |
|
Description: Primary antibody against LEC Chemokine(LEC67), CF770 conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNC800066-100 | Biotium | 100uL | EUR 238.8 |
|
Description: Primary antibody against LEC Chemokine(LEC66), CF680 conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNC800066-500 | Biotium | 500uL | EUR 652.8 |
|
Description: Primary antibody against LEC Chemokine(LEC66), CF680 conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNC800067-100 | Biotium | 100uL | EUR 238.8 |
|
Description: Primary antibody against LEC Chemokine(LEC67), CF680 conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNC800067-500 | Biotium | 500uL | EUR 652.8 |
|
Description: Primary antibody against LEC Chemokine(LEC67), CF680 conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNCB0066-100 | Biotium | 100uL | EUR 238.8 |
|
Description: Primary antibody against LEC Chemokine(LEC66), Biotin conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNCB0066-500 | Biotium | 500uL | EUR 652.8 |
|
Description: Primary antibody against LEC Chemokine(LEC66), Biotin conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNCB0067-100 | Biotium | 100uL | EUR 238.8 |
|
Description: Primary antibody against LEC Chemokine(LEC67), Biotin conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNCB0067-500 | Biotium | 500uL | EUR 652.8 |
|
Description: Primary antibody against LEC Chemokine(LEC67), Biotin conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNC940066-100 | Biotium | 100uL | EUR 238.8 |
|
Description: Primary antibody against LEC Chemokine(LEC66), CF594 conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNC940066-500 | Biotium | 500uL | EUR 652.8 |
|
Description: Primary antibody against LEC Chemokine(LEC66), CF594 conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNC940067-100 | Biotium | 100uL | EUR 238.8 |
|
Description: Primary antibody against LEC Chemokine(LEC67), CF594 conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNC940067-500 | Biotium | 500uL | EUR 652.8 |
|
Description: Primary antibody against LEC Chemokine(LEC67), CF594 conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNC550066-100 | Biotium | 100uL | EUR 238.8 |
|
Description: Primary antibody against LEC Chemokine(LEC66), CF555 conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNC550066-500 | Biotium | 500uL | EUR 652.8 |
|
Description: Primary antibody against LEC Chemokine(LEC66), CF555 conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNC550067-100 | Biotium | 100uL | EUR 238.8 |
|
Description: Primary antibody against LEC Chemokine(LEC67), CF555 conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC67) Antibody |
|||
| BNC550067-500 | Biotium | 500uL | EUR 652.8 |
|
Description: Primary antibody against LEC Chemokine(LEC67), CF555 conjugate, Concentration: 0.1mg/mL |
|||
LEC Chemokine(LEC66) Antibody |
|||
| BNCH0066-100 | Biotium | 100uL | EUR 238.8 |
|
Description: Primary antibody against LEC Chemokine(LEC66), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
|||
