Category: estradiol elisa

December 14, 2020

Developing HME-Based Drug Products Using Emerging Science: a Fast-Track Roadmap from Concept to Clinical Batch

This paper presents a rational workflow for growing enabling formulations, similar to amorphous strong dispersions, through hot-melt extrusion in lower than a yr. First, our strategy to an built-in product and course of improvement framework is described, together with state-of-the-art theoretical ideas, modeling, and experimental characterization described within the literature and developed by us. Subsequent, lab-scale extruder setups are designed (processing situations and screw design) […]

December 14, 2020

How Do We Measure Poly- and Perfluoroalkyl Substances (PFASs) at the Surface of Consumer Products?: Environmental Science and Technology LETTERS

Exposures to poly- and perfluoroalkyl substances (PFASs) have been linked to metabolic disruption, immunotoxicity and most cancers in people. PFASs are identified to be current in numerous client merchandise together with textiles and meals packaging. Right here we current a brand new technique for quantifying the atomic p.c fluorine (% F) within the surficial 0.01 μm of client merchandise utilizing X-ray photoelectron spectroscopy (XPS). The […]

August 24, 2020

Research for Disulfide-Linked, Self-Immolating Subsequent-Technology Antibody Drug

Conjugation Site Influences Antibody-Conjugated Drug PK Assays: Case Studies for Disulfide-Linked, Self-Immolating Next-Generation Antibody Drug Conjugates   Immunoaffinity (IA) LC-MS/MS pharmacokinetic (PK) assays are widely used in the field for antibody drug conjugates (ADCs) containing peptide linkers that are enzymatically cleavable, such as MC-ValCit-PAB. Conjugate PK assay strategies for these ADCs involve cleavage with cathepsin B or papain to release and measure the antibody-conjugated drug (acDrug) concentration. However, […]