Author: Karina

December 14, 2020

Exploring the inclusion of teaching and learning on assistive products in undergraduate curricula of health sciences faculties at three South African Universities.

Suppliers have to be educated on coverage, techniques and merchandise to supply an individual centred service and prescribe essentially the most acceptable assistive product for every consumer.Goal: This examine aimed to find out to what extent instructing and studying on assistive merchandise are included in undergraduate curricula of the Well being science schools at three universities within the Western Cape Province of South Africa. Strategies: Knowledge had […]

December 14, 2020

Developing HME-Based Drug Products Using Emerging Science: a Fast-Track Roadmap from Concept to Clinical Batch

This paper presents a rational workflow for growing enabling formulations, similar to amorphous strong dispersions, through hot-melt extrusion in lower than a yr. First, our strategy to an built-in product and course of improvement framework is described, together with state-of-the-art theoretical ideas, modeling, and experimental characterization described within the literature and developed by us. Subsequent, lab-scale extruder setups are designed (processing situations and screw design) […]

December 14, 2020

How Do We Measure Poly- and Perfluoroalkyl Substances (PFASs) at the Surface of Consumer Products?: Environmental Science and Technology LETTERS

Exposures to poly- and perfluoroalkyl substances (PFASs) have been linked to metabolic disruption, immunotoxicity and most cancers in people. PFASs are identified to be current in numerous client merchandise together with textiles and meals packaging. Right here we current a brand new technique for quantifying the atomic p.c fluorine (% F) within the surficial 0.01 μm of client merchandise utilizing X-ray photoelectron spectroscopy (XPS). The […]

August 24, 2020

Research for Disulfide-Linked, Self-Immolating Subsequent-Technology Antibody Drug

Conjugation Site Influences Antibody-Conjugated Drug PK Assays: Case Studies for Disulfide-Linked, Self-Immolating Next-Generation Antibody Drug Conjugates   Immunoaffinity (IA) LC-MS/MS pharmacokinetic (PK) assays are widely used in the field for antibody drug conjugates (ADCs) containing peptide linkers that are enzymatically cleavable, such as MC-ValCit-PAB. Conjugate PK assay strategies for these ADCs involve cleavage with cathepsin B or papain to release and measure the antibody-conjugated drug (acDrug) concentration. However, […]

August 24, 2020

Antibody-Protein binding and Conformational changes

A high-throughput neutralizing antibody assay for COVID-19 analysis and vaccine analysis   Virus neutralization stays the gold normal for figuring out antibody efficacy. Due to this fact, a high-throughput assay to measure SARS-CoV-2 neutralizing antibodies is urgently wanted for COVID-19 serodiagnosis, convalescent plasma remedy, and vaccine growth. Right here, we report on a fluorescence-based SARS-CoV-2 neutralization assay that detects SARS-CoV-2 neutralizing antibodies in COVID-19 affected person […]